Results 61 to 70 of about 2,762 (187)

A test of genetic divergence of a bird existing in the Sichuan Basin and its surrounding mountain ranges

Avian Research, 2023
Island ecosystems, serving as natural laboratories, facilitate geographical isolation, ecological specialization, and species divergence. The Sichuan Basin, surrounded by mountain ranges, represents a typical continental island due to its marked ...
Lu Wang, Fangqing Liu, Lan Zhao, Yaling Xu, Tianyu Zhang, Longying Wen   +5 more
doaj   +1 more source

Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]

, 2018
Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia, Anna, Jeffreys, Bancone, G., Benjamin, Tsofa, Carolyne, M Ndila, Christina, Hubbart, Dominic, P Kwiatkowski, Gavin, Band, Geraldine, Clarke, Gideon, Nyutu, Hughes, C., John, Ojal, Kate, Rowlands, Kathryn, Maitland, Kennedy, O Awuondo, Kevin, Marsh, Kirk, A Rockett, Malariagen, Consortium, Mangano, V., Margaret, Mackinnon, Modiano, David, Mohammed, Shebe, Neema, Mturi, Norbert, Peshu, Nuno, Sepúlveda, Silvia, Kariuki, Sophie, Uyoga, Taane, G Clark, Thomas, N Williams   +28 more
core   +1 more source

Duplications of the critical Rubinstein-Taybi deletion region on chromosome 16p13.3 cause a novel recognisable syndrome [PDF]

, 2010
Background The introduction of molecular karyotyping technologies facilitated the identification of specific genetic disorders associated with imbalances of certain genomic regions.
Bena, F, Bottani, A, Breckpot, J, Cheung, SW, Devriendt, K, Fong, CT, Friedman, JM, Fryns, JP, Gimelli, S, Gorski, JL, Grange, DK, Kussmann, JL, Menten, Björn, Morris, MM, Mortier, Geert, Philip, N, Salamone, JM, Scalais, E, Thienpont, B, Van Esch, H, Vermeesch, JR, Villard, L, Yong, SL, Zahir, F   +23 more
core   +2 more sources

Association between genetic risk score and tri-ponderal mass index growth trajectories among different dietary consumption adolescents in a prospective Taiwanese cohort

Nutrition & Metabolism, 2022
Background Single-nucleotide polymorphisms (SNPs) in various genetic loci are associated with childhood obesity; however, their influence on adolescent growth patterns has rarely been explored.
Yi-Fan Wu, Kuo-Liong Chien, Yang-Ching Chen   +2 more
doaj   +1 more source

Expression and clinical significance of 3 kinds of circular RNA in systemic lupus erythematosus

Di-san junyi daxue xuebao, 2020
Objective To explore the expression and significance of 3 circular RNAs (circRNA), that is, circADCY9, circGARS and circMCTP2, in the patients with systemic lupus erythematosus (SLE), so as to provide new ideas and directions for its clinical diagnosis ...
GUO Junkai1, ZHAO Xingwang, NI Bing, YOU Yi   +3 more
doaj   +1 more source

Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]

, 2018
Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun, Ellisman, Mark H, Jeong, Seung Won, Ju, Won-Kyu, Kim, Keun-Young, Nam, Hye Seung, Park, Tae Lim, Shim, Myoung Sup, Weinreb, Robert N   +8 more
core   +2 more sources

Human candidate polymorphisms in sympatric ethnic groups differing in malaria susceptibility in Mali.

PLoS ONE, 2013
Malaria still remains a major public health problem in Mali, although disease susceptibility varies between ethnic groups, particularly between the Fulani and Dogon. These two sympatric groups share similar socio-cultural factors and malaria transmission
Bakary Maiga, Amagana Dolo, Ousmane Touré, Victor Dara, Amadou Tapily, Susana Campino, Nuno Sepulveda, Paul Risley, Nilupa Silva, Patrick Corran, Kirk A Rockett, Dominic Kwiatkowski, MalariaGEN Consortium, Taane G Clark, Marita Troye-Blomberg, Ogobara K Doumbo   +15 more
doaj   +1 more source

Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy

Frontiers in Pharmacology, 2019
Asthma is a frequent disease, mainly characterized by airway inflammation, in which drug therapy is crucial in its management. The potential of pharmacogenomics testing in asthma therapy has been, to date, little explored.
Jesús Miguel García-Menaya, Concepción Cordobés-Durán, Elena García-Martín, José A. G. Agúndez   +3 more
doaj   +1 more source

Comprehensive assessments of germline deletion structural variants reveal the association between prognostic MUC4 and CEP72 deletions and immune response gene expression in colorectal cancer patients

Human Genomics, 2021
Background Functional disruptions by large germline genomic structural variants in susceptible genes are known risks for cancer. We used deletion structural variants (DSVs) generated from germline whole-genome sequencing (WGS) and DSV immune-related ...
Peng-Chan Lin, Hui-O Chen, Chih-Jung Lee, Yu-Min Yeh, Meng-Ru Shen, Jung-Hsien Chiang   +5 more
doaj   +1 more source

Female Anterior Cruciate Ligaments Exhibit a Muted Mechanobiological Response to Mechanical Loading

Journal of Orthopaedic Research, Volume 43, Issue 12, Page 2188-2202, December 2025.
ABSTRACT Female athletes are significantly more likely to tear their anterior cruciate ligament (ACL) compared to their male counterparts. While there are several potential reasons for this, previous data from our lab demonstrated that female ACL explants have an impaired remodeling response to loading, which may prevent the repair of fatigue damage ...
Lauren Paschall, Maxwell Konnaris, Erdem Tabdanov, Aman Dhawan, Spencer E. Szczesny   +4 more
wiley   +1 more source