Human Genomics, 2021 Background Functional disruptions by large germline genomic structural variants in susceptible genes are known risks for cancer. We used deletion structural variants (DSVs) generated from germline whole-genome sequencing (WGS) and DSV immune-related ...
Peng-Chan Lin +5 more
doaj +1 more source
Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species [PDF]
, 2018 The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary ...
Alles, Julia +11 more
core +1 more source
Expression and clinical significance of 3 kinds of circular RNA in systemic lupus erythematosus
Di-san junyi daxue xuebao, 2020 Objective To explore the expression and significance of 3 circular RNAs (circRNA), that is, circADCY9, circGARS and circMCTP2, in the patients with systemic lupus erythematosus (SLE), so as to provide new ideas and directions for its clinical diagnosis ...
GUO Junkai1 +3 more
doaj +1 more source
Role of adenylate cyclase 9 in the pharmacogenomic response to dalcetrapib clinical paradigm and molecular mechanisms in precision cardiovascular medicine [PDF]
, 2021 Following the neutral results of the dal-OUTCOMES trial, a genome-wide study identified the rs1967309 variant in the adenylate cyclase type 9 (ADCY9) gene on chromosome 16 as being associated with the risk of future cardiovascular events only in subjects
Black, D.M. +13 more
core +2 more sources
Epstein-Barr Virus EBER Transcripts Affect miRNA-Mediated Regulation of Specific Targets and Are Processed to Small RNA Species [PDF]
, 2015 The oncogenic Epstein-Barr virus (EBV) expresses 44 mature microRNAs and two non-coding EBER RNAs of 167 (EBER1) and 172 (EBER2) nt length. MiRNA profiling of NK/T cell lines and primary cells and Northern blotting of EBV-infected cell lines and primary ...
Alles, J. +4 more
core +1 more source
Crtc1 activates a transcriptional program deregulated at early Alzheimer's disease-related stages [PDF]
, 2014 Cognitive decline is associated with gene expression changes in the brain, but the transcriptional mechanisms underlying memory impairments in cognitive disorders, such as Alzheimer's disease (AD), are largely unknown.
Chen, Meng +7 more
core +5 more sources
Pharmacogenetic Factors Affecting Asthma Treatment Response. Potential Implications for Drug Therapy
Frontiers in Pharmacology, 2019 Asthma is a frequent disease, mainly characterized by airway inflammation, in which drug therapy is crucial in its management. The potential of pharmacogenomics testing in asthma therapy has been, to date, little explored.
Jesús Miguel García-Menaya +3 more
doaj +1 more source
Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study [PDF]
, 2018 Background: Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms—many related to the structure or function of red blood cells—and risk for severe Plasmodium falciparum ...
Alexander, W Macharia +28 more
core +1 more source
Pharmacogenomics of blood lipid regulation [PDF]
, 2018 Blood lipids are important modifiable risk factors for coronary heart disease and drugs target different lipid fractions. Considerable efforts have been made to identify genetic variants that modulate responses to drugs in the hope of optimizing their ...
Dubé, Marie-Pierre +2 more
core +1 more source
Massive rearrangements of cellular MicroRNA signatures are key drivers of hepatocyte dedifferentiation [PDF]
, 2016 Hepatocytes are dynamic cells that, upon injury, can alternate between nondividing differentiated and dedifferentiated proliferating states in vivo .
Andersson, TB +14 more
core +1 more source