Results 81 to 90 of about 2,762 (187)

Genetic Landscape of Obesity in Children: Research Advances and Prospects

Journal of Obesity, Volume 2025, Issue 1, 2025.
Obesity is a chronic metabolic disease characterized by excessive accumulation or uneven distribution of fat in the body, which poses a serious threat to health. Obesity significantly increases the risk of developing сonditions such as type 2 diabetes, coronary heart disease, hypertension, obstructive sleep apnea, and some types of cancer.
Rita Khusainova, Ildar Minniakhmetov, Olga Vasyukova, Bulat Yalaev, Ramil Salakhov, Darya Kopytina, Raisat Guseinova, Ekaterina Dobreva, Galina Melnichenko, Ivan Dedov, Natalia Mokrysheva, Claire Stocker   +11 more
wiley   +1 more source

Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature [PDF]

, 2016
Childhood maltreatment is associated with increased severity of substance use disorder and frequent relapse to drug use following abstinence. However, the molecular and neurobiological substrates that are engaged during early traumatic events and ...
Aricò, Eleonora, Bisicchia, Elisa, Carola, Valeria, Castiello, Luciano, D'Amato, Francesca R., Ermakova, Olga, LO IACONO, Luisa, Oddi, Diego, PUGLISI ALLEGRA, Stefano, Valzania, Alessandro, VISCO COMANDINI, Federica, Viscomi, Maria Teresa   +11 more
core   +1 more source

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Nature Genetics, 2013
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population.
S. I. Berndt, S. Gustafsson, R. Mägi, A. Ganna, E. Wheeler, M. Feitosa, A. Justice, K. Monda, Damien C. Croteau-Chonka, F. Day, T. Esko, T. Fall, T. Ferreira, Davide Gentilini, A. Jackson, J. Luan, J. Randall, S. Vedantam, C. Willer, T. Winkler, A. Wood, T. Workalemahu, Yi-Juan Hu, S. Lee, Liming Liang, Dan-yu Lin, J. Min, B. Neale, G. Thorleifsson, Jian Yang, E. Albrecht, N. Amin, J. Bragg-Gresham, G. Cadby, M. den Heijer, N. Eklund, K. Fischer, A. Goel, J. Hottenga, J. Huffman, I. Jarick, Å. Johansson, T. Johnson, S. Kanoni, M. Kleber, I. König, K. Kristiansson, Z. Kutalik, C. Lamina, C. Lecoeur, Guo Li, M. Mangino, W. McArdle, C. Medina-Gomez, Martina Müller-Nurasyid, J. Ngwa, I. Nolte, L. Paternoster, S. Pechlivanis, M. Perola, M. Peters, Michael H. Preuss, L. Rose, Jianxin Shi, D. Shungin, A. Smith, R. Strawbridge, I. Surakka, A. Teumer, M. Trip, J. Tyrer, Jana V. van Vliet-Ostaptchouk, L. Vandenput, L. Waite, Jinghua Zhao, D. Absher, F. Asselbergs, M. Atalay, A. Attwood, A. Balmforth, H. Basart, J. Beilby, L. Bonnycastle, Paolo Brambilla, M. Bruinenberg, Harry Campbell, D. Chasman, P. Chines, F. Collins, J. Connell, W. Cookson, U. de Faire, F. de Vegt, Mariano Dei, M. Dimitriou, S. Edkins, K. Estrada, David M. Evans, M. Farrall, M. M. Ferrario, J. Ferrières, L. Franke, F. Frau, P. Gejman, H. Grallert, Henrik Grönberg, V. Gudnason, Alistair S. Hall, Per Hall, Anna-Liisa Hartikainen, C. Hayward, N. Heard-Costa, A. Heath, J. Hebebrand, G. Homuth, Frank Hu, S. Hunt, Elina Hyppönen, C. Iribarren, K. Jacobs, J. Jansson, A. Jula, M. Kähönen, S. Kathiresan, F. Kee, K. Khaw, M. Kivimäki, Wolfgang Koenig, A. Kraja, M. Kumari, K. Kuulasmaa, J. Kuusisto, J. Laitinen, T. Lakka, C. Langenberg, L. Launer, L. Lind, J. Lindström, Jianjun Liu, Antonio Liuzzi, M. Lokki, M. Lorentzon, P. Madden, P. Magnusson, P. Manunta, Diana Marek, Winfried März, I. M. Leach, Barbara McKnight, S. Medland, E. Mihailov, L. Milani, G. Montgomery, V. Mooser, Thomas W. Mühleisen, P. Munroe, A. Musk, Narisu Narisu, G. Navis, G. Nicholson, E. Nohr, Ken K. Ong, B. Oostra, Colin N. A. Palmer, A. Palotie, J. Peden, N. Pedersen, Annette Peters, O. Polašek, A. Pouta, P. Pramstaller, I. Prokopenko, C. Pütter, A. Radhakrishnan, O. Raitakari, A. Rendon, F. Rivadeneira, I. Rudan, T. Saaristo, J. Sambrook, A. Sanders, S. Sanna, J. Saramies, S. Schipf, S. Schreiber, Heribert Schunkert, So-Youn Shin, Stefano Signorini, J. Sinisalo, Boris Skrobek, N. Soranzo, A. Stančáková, K. Stark, J. Stephens, K. Stirrups, R. Stolk, M. Stumvoll, A. Swift, E. Theodoraki, B. Thorand, D. Tregouet, E. Tremoli, M. M. van der Klauw, J. V. van Meurs, S. Vermeulen, J. Viikari, J. Virtamo, V. Vitart, G. Waeber, Z. Wang, E. Widén, Sarah H Wild, G. Willemsen, B. Winkelmann, J. Witteman, B. Wolffenbuttel, A. Wong, Alan F. Wright, M. Zillikens, P. Amouyel, Bernhard O. Boehm, E. Boerwinkle, D. Boomsma, M. Caulfield, S. Chanock, L. Cupples, D. Cusi, G. Dedoussis, J. Erdmann, J. Eriksson, P. Franks, P. Froguel, C. Gieger, U. Gyllensten, A. Hamsten, T. Harris, C. Hengstenberg, A. Hicks, A. Hingorani, A. Hinney, A. Hofman, K. Hovingh, K. Hveem, T. Illig, M. Jarvelin, K. Jöckel, S. Keinanen-Kiukaanniemi, L. Kiemeney, D. Kuh, M. Laakso, T. Lehtimäki, D. Levinson, N. G. Martin, A. Metspalu, Andrew D. Morris, Markku S Nieminen, I. Njølstad, Claes Ohlsson, A. Oldehinkel, W. Ouwehand, L. Palmer, B. Penninx, C. Power, M. Province, B. Psaty, Lu Qi, R. Rauramaa, P. Ridker, S. Ripatti, V. Salomaa, N. Samani, H. Snieder, T. I. Sørensen, T. Spector, K. Stefansson, A. Tönjes, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. van der Harst, P. Vollenweider, H. Wallaschofski, N. Wareham, Hugh Watkins, H. Wichmann, James F. Wilson, G. Abecasis, T. Assimes, I. Barroso, M. Boehnke, I. Borecki, P. Deloukas, C. Fox, T. Frayling, L. Groop, Talin Haritunian, I. Heid, David J. Hunter, R. C. Kaplan, F. Karpe, M. Moffatt, K. Mohlke, J. O’Connell, Y. Pawitan, E. Schadt, D. Schlessinger, V. Steinthorsdottir, David P. Strachan, U. Thorsteinsdóttir, C. V. van Duijn, P. Visscher, A. Di Blasio, J. Hirschhorn, C. Lindgren, Andrew P Morris, D. Meyre, A. Scherag, M. McCarthy, Elizabeth K. Speliotes, K. North, Ruth J. F. Loos, E. Ingelsson   +321 more
semanticscholar   +1 more source

Insights into RNA‐mediated pathology in new mouse models of Huntington's disease

The FASEB Journal, Volume 38, Issue 23, 15 December 2024.
The behavioral and molecular characterization was performed for Huntington's disease mouse models expressing a fragment of the human HTT gene, with mutation of ~100 CAG repeats, in the nontranslated version (HD/100CAG) and the translated version (HD/100Q). Abstract Huntington's disease (HD) is a neurodegenerative polyglutamine (polyQ) disease resulting
Magdalena Wozna‐Wysocka, Magdalena Jazurek‐Ciesiolka, Lukasz Przybyl, Dorota Wronka, Julia Oliwia Misiorek, Joanna Suszynska‐Zajczyk, Grzegorz Figura, Adam Ciesiolka, Paula Sobieszczanska, Anna Zeller, Magdalena Niemira, Pawel Michal Switonski, Agnieszka Fiszer   +12 more
wiley   +1 more source

The hypoxia adaptation strategy of the big-belly seahorses (Hippocampus abdominalis) with tuft gills

Aquaculture Reports
Hypoxia tolerance is a critical trait in fish breeding, however, the mechanisms underlying hypoxia regulation in the tuft gills of seahorses remain unclear.
Long-Wu Jia, Le-Le Zhang, Hong-Wei Yang, Chun-Yu Hou, Lin Shi, Yu-Ping Hou, Guo-Dong Zheng, Xiao-Lei Su, Kai Wang   +8 more
doaj   +1 more source

Drivers of genomic diversity and phenotypic development in early phases of domestication in Hermetia illucens

Insect Molecular Biology, Volume 33, Issue 6, Page 756-776, December 2024.
Random drift rather than selection is the primary evolutionary force driving genomic and phenotypic variation in BSF populations during early phases of domestication. Functional trade‐offs between production and fitness traits were observed in BSF populations.
Kelvin L. Hull, Matthew P. Greenwood, Melissa Lloyd, Marissa Brink‐Hull, Aletta E. Bester‐van der Merwe, Clint Rhode   +5 more
wiley   +1 more source

Is personalized medicine achievable in obstetrics? [PDF]

, 2014
Personalized medicine seeks to identify the right dose of the right drug for the right patient at the right time. Typically, individualization of therapy is based on the pharmacogenomic makeup of the individual and environmental factors that alter drug ...
Flockhart, David A., Patil, Avinash S., Quinney, Sara K.   +2 more
core   +1 more source

Paraoxonase‐2 agonist vutiglabridin promotes autophagy activation and mitochondrial function to alleviate non‐alcoholic steatohepatitis

British Journal of Pharmacology, Volume 181, Issue 19, Page 3717-3742, October 2024.
Abstract Background and Purpose Only limited therapeutic agents have been developed for non‐alcoholic steatohepatitis (NASH). Glabridin, a promising anti‐obesity candidate, has only limited druggability due to its low in vivo chemical stability and bioavailability.
Gu‐Choul Shin, Hyeong Min Lee, Nayeon Kim, Jihyeon Hur, Sang‐Ku Yoo, Yun Sun Park, Hyung Soon Park, Dongryeol Ryu, Min‐Ho Park, Jung Hee Park, Sang‐Uk Seo, Leo Sungwong Choi, Martin Rønn Madsen, Michael Feigh, Kwang Pyo Kim, Kyun‐Hwan Kim   +15 more
wiley   +1 more source

A Five-microRNA Signature as Prognostic Biomarker in Colorectal Cancer by Bioinformatics Analysis

Frontiers in Oncology, 2019
Mounting evidence has demonstrated that a lot of miRNAs are overexpressed or downregulated in colorectal cancer (CRC) tissues and play a crucial role in tumorigenesis, invasion, and migration.
Guodong Yang, Yujiao Zhang, Jiyuan Yang
doaj   +1 more source

Integration of multiomics data identifies candidate genes influencing pH levels in Beijing Black pigs

Animal Research and One Health, Volume 2, Issue 3, Page 260-272, August 2024.
To explore the genetic mechanism of pH values, we measured the pH values at 2 h (pH2h) and 24 h (pH24h) postmortem in the longissimus dorsi muscle of Beijing Black pigs. A total of 614 Beijing Black pigs were genotyped by the Illumina Porcine 50K SNP Chip. We conducted a genome‐wide association study and RNA sequencing (RNA‐seq) analysis.
Jingjing Tian, Naiqi Niu, Xiaoqing Wang, Liangyu Shi, Liyu Yang, Mianyan Li, Lijun Shi, Xin Liu, Hongmei Gao, Xinhua Hou, Ligang Wang, Lixian Wang, Longchao Zhang, Fuping Zhao   +13 more
wiley   +1 more source