Results 81 to 90 of about 2,141 (173)

Physiological responses to a changing winter climate in an early spring‐breeding amphibian

Ecology and Evolution, Volume 14, Issue 7, July 2024.
Climate change is swiftly altering environmental winter conditions, leading to significant ecological impacts such as phenological shifts in many species. Our study points for the first time to the complex physiological challenges that amphibians face as a result of changing thermal conditions due to winter climate change.
Robin Schmidt, Cecile Zummach, Noa Sinai, Joana Sabino‐Pinto, Sven Künzel, Kathrin H. Dausmann, Katharina Ruthsatz   +6 more
wiley   +1 more source

Additional file 1 of Role of the ADCY9 gene in cardiac abnormalities of the Rubinstein-Taybi syndrome

, 2020
Additional file 1.
Wu, Yueheng, Xia, Yu, Li, Ping, Qu, Hui-Qi, Liu, Yichuan, Yang, Yongchao, Lin, Jijin, Zheng, Meng, Tian, Lifeng, Wu, Zhuanbin, Huang, Shufang, Qin, Xianyu, Zhou, Xianwu, Chen, Shaoxian, Liu, Yanying, Wang, Yonghua, Li, Xiaofeng, Zeng, Hanshi, Hakonarson, Hakon, Zhuang, Jian   +19 more
openaire   +1 more source

Adenylyl cyclase 2 expression and function in neurological diseases

CNS Neuroscience &Therapeutics, Volume 30, Issue 7, July 2024.
Mutations and expression changes of adenylyl cyclase 2 (Adcy2), a CNS‐enriched enzyme that converts ATP to cAMP, are associated with several neurodegenerative and psychiatric disorders. Abstract Adenylyl cyclases (Adcys) catalyze the formation of cAMP, a secondary messenger essential for cell survival and neurotransmission pathways in the CNS.
Marsilla Gray, Kevin R. Nash, Yao Yao
wiley   +1 more source

Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture

Nature Genetics, 2013
Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population.
S. I. Berndt, S. Gustafsson, R. Mägi, A. Ganna, E. Wheeler, M. Feitosa, A. Justice, K. Monda, Damien C. Croteau-Chonka, F. Day, T. Esko, T. Fall, T. Ferreira, Davide Gentilini, A. Jackson, J. Luan, J. Randall, S. Vedantam, C. Willer, T. Winkler, A. Wood, T. Workalemahu, Yi-Juan Hu, S. Lee, Liming Liang, Dan-yu Lin, J. Min, B. Neale, G. Thorleifsson, Jian Yang, E. Albrecht, N. Amin, J. Bragg-Gresham, G. Cadby, M. den Heijer, N. Eklund, K. Fischer, A. Goel, J. Hottenga, J. Huffman, I. Jarick, Å. Johansson, T. Johnson, S. Kanoni, M. Kleber, I. König, K. Kristiansson, Z. Kutalik, C. Lamina, C. Lecoeur, Guo Li, M. Mangino, W. McArdle, C. Medina-Gomez, Martina Müller-Nurasyid, Julius S. Ngwa, I. Nolte, L. Paternoster, S. Pechlivanis, M. Perola, M. Peters, Michael H. Preuss, L. Rose, Jianxin Shi, D. Shungin, A. Smith, R. Strawbridge, I. Surakka, A. Teumer, M. Trip, J. Tyrer, Jana V. van Vliet-Ostaptchouk, L. Vandenput, L. Waite, Jinghua Zhao, D. Absher, F. Asselbergs, M. Atalay, A. Attwood, A. Balmforth, H. Basart, J. Beilby, L. Bonnycastle, Paolo Brambilla, M. Bruinenberg, Harry Campbell, D. Chasman, P. Chines, F. Collins, J. Connell, W. Cookson, U. de Faire, F. de Vegt, Mariano Dei, M. Dimitriou, S. Edkins, K. Estrada, David M. Evans, M. Farrall, M. M. Ferrario, J. Ferrières, L. Franke, F. Frau, P. Gejman, H. Grallert, Henrik Grönberg, V. Gudnason, Alistair S. Hall, Per Hall, Anna-Liisa Hartikainen, C. Hayward, N. Heard-Costa, Andrew C. Heath, J. Hebebrand, G. Homuth, Frank Hu, S. Hunt, Elina Hyppönen, C. Iribarren, K. Jacobs, J. Jansson, A. Jula, M. Kähönen, S. Kathiresan, F. Kee, K. Khaw, M. Kivimäki, Wolfgang Koenig, A. Kraja, M. Kumari, K. Kuulasmaa, J. Kuusisto, J. Laitinen, T. Lakka, C. Langenberg, L. Launer, L. Lind, J. Lindström, Jianjun Liu, Antonio Liuzzi, M. Lokki, M. Lorentzon, P. Madden, P. Magnusson, P. Manunta, Diana Marek, Winfried März, I. M. Leach, Barbara McKnight, S. Medland, E. Mihailov, L. Milani, G. Montgomery, V. Mooser, Thomas W. Mühleisen, P. Munroe, A. Musk, Narisu Narisu, G. Navis, G. Nicholson, E. Nohr, Ken K. Ong, B. Oostra, Colin N. A. Palmer, A. Palotie, J. Peden, Nancy L Pedersen, Annette Peters, O. Polašek, A. Pouta, P. Pramstaller, I. Prokopenko, C. Pütter, A. Radhakrishnan, O. Raitakari, A. Rendon, F. Rivadeneira, I. Rudan, T. Saaristo, J. Sambrook, A. Sanders, S. Sanna, J. Saramies, S. Schipf, S. Schreiber, Heribert Schunkert, So-Youn Shin, S. Signorini, J. Sinisalo, Boris Skrobek, N. Soranzo, A. Stančáková, K. Stark, J. Stephens, K. Stirrups, R. Stolk, M. Stumvoll, A. Swift, E. Theodoraki, B. Thorand, D. Tregouet, E. Tremoli, M. M. van der Klauw, J. V. van Meurs, S. Vermeulen, J. Viikari, J. Virtamo, V. Vitart, G. Waeber, Z. Wang, E. Widén, Sarah H Wild, G. Willemsen, B. Winkelmann, J. Witteman, B. Wolffenbuttel, A. Wong, Alan F. Wright, M. Zillikens, P. Amouyel, Bernhard O. Boehm, E. Boerwinkle, D. Boomsma, M. Caulfield, S. Chanock, L. Cupples, D. Cusi, G. Dedoussis, J. Erdmann, J. Eriksson, P. Franks, P. Froguel, C. Gieger, U. Gyllensten, A. Hamsten, T. Harris, C. Hengstenberg, A. Hicks, A. Hingorani, A. Hinney, A. Hofman, K. Hovingh, K. Hveem, T. Illig, M. Jarvelin, K. Jöckel, S. Keinanen-Kiukaanniemi, L. Kiemeney, D. Kuh, M. Laakso, T. Lehtimäki, D. Levinson, N. G. Martin, A. Metspalu, Andrew D. Morris, Markku S Nieminen, I. Njølstad, Claes Ohlsson, A. Oldehinkel, W. Ouwehand, L. Palmer, B. Penninx, C. Power, M. Province, B. Psaty, Lu Qi, R. Rauramaa, P. Ridker, S. Ripatti, V. Salomaa, N. Samani, H. Snieder, T. I. Sørensen, T. Spector, K. Stefansson, A. Tönjes, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. van der Harst, P. Vollenweider, H. Wallaschofski, N. Wareham, Hugh Watkins, H. Wichmann, James F. Wilson, G. Abecasis, T. Assimes, I. Barroso, M. Boehnke, I. Borecki, P. Deloukas, C. Fox, T. Frayling, L. Groop, Talin Haritunian, I. Heid, David J. Hunter, R. C. Kaplan, F. Karpe, M. Moffatt, K. Mohlke, J. O’Connell, Y. Pawitan, E. Schadt, D. Schlessinger, V. Steinthorsdottir, David P. Strachan, U. Thorsteinsdóttir, C. V. van Duijn, P. Visscher, A. Di Blasio, J. Hirschhorn, C. Lindgren, Andrew P Morris, D. Meyre, A. Scherag, M. McCarthy, Elizabeth K. Speliotes, K. North, Ruth J. F. Loos, E. Ingelsson   +321 more
semanticscholar   +1 more source

Unveiling blood pressure‐associated genes in aortic cells through integrative analysis of GWAS and RNA modification‐associated variants

Chronic Diseases and Translational Medicine, Volume 10, Issue 2, Page 118-129, June 2024.
Differential expression genes in single‐cell transcriptomic sequencing study. (A) Uniform Manifold Approximation and Projection (UMAP) visualization showcasing distinct immune cell types among six cases and seven controls. (B) Volcano plot displaying differential expression genes between aortic dissection patients and controls.
Huan Zhang, Yuxi Chen, Peng Xu, Dan Liu, Naqiong Wu, Laiyuan Wang, Xingbo Mo   +6 more
wiley   +1 more source

A Five-microRNA Signature as Prognostic Biomarker in Colorectal Cancer by Bioinformatics Analysis

Frontiers in Oncology, 2019
Mounting evidence has demonstrated that a lot of miRNAs are overexpressed or downregulated in colorectal cancer (CRC) tissues and play a crucial role in tumorigenesis, invasion, and migration.
Guodong Yang, Yujiao Zhang, Jiyuan Yang
doaj   +1 more source

DNA methylation and transcriptome analysis reveal epigenomic differences among three macaque species

Evolutionary Applications, Volume 17, Issue 2, February 2024.
Abstract Macaques (genus Macaca) are the most widely distributed non‐human primates, and their evolutionary history, gene expression profiles, and genetic differences have been extensively studied. However, the DNA methylomes of macaque species are not available in public databases, which hampers understanding of epigenetic differences among macaque ...
Jiao Wang, Xuyuan Liu, Yue Lan, Tengcheng Que, Jing Li, Bisong Yue, Zhenxin Fan   +6 more
wiley   +1 more source

Genome-wide DNA methylation pattern in visceral adipose tissue differentiates insulin-resistant from insulin-sensitive obese subject [PDF]

, 2017
Elucidating the potential mechanisms involved in the detrimental effect of excess body weight on insulin action is an important priority in counteracting obesity-associated diseases.
Casanueva, Felipe F., Crujeiras, Ana B., Diaz-Lagares, Angel, Esteller, Manel, Fernandez-Real, J. M., Gomez, A., Hervas, David, Moreno-Navarrete, José María, Ricart Engel, Wifredo, Sandoval, Juan   +9 more
core   +1 more source

DNA methylation in genes of longevity‐regulating pathways: association with obesity and metabolic complications [PDF]

, 2019
Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylation (DNAm) plays a pivotal role in the regulation of physiological responses that can vary along lifespan.
Mansego-Talavera, M.L. (María Luisa), Martinez, J.A. (José Alfredo), Milagro-Yoldi, F.I. (Fermín Ignacio), Ramos-López, O. (Omar), Riezu-Boj, J.I. (José Ignacio), Salas-Pérez, F. (Francisca), Santos, J.L. (José Luis)   +6 more
core  

Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas [PDF]

, 2007
BACKGROUND: The Allen Brain Atlas (ABA) project systematically profiles three-dimensional high-resolution gene expression in postnatal mouse brains for thousands of genes.
Jiang, Tao, Li, Jing, Liu, Zheng, Walker, John R, Yan, S Frank, Zhou, Yingyao, Zwingman, Theresa A   +6 more
core   +3 more sources