Elevated intracellular cAMP exacerbates vulnerability to oxidative stress in optic nerve head astrocytes. [PDF]
, 2018 Glaucoma is characterized by a progressive loss of retinal ganglion cells and their axons, but the underlying biological basis for the accompanying neurodegeneration is not known.
Bu, Jung Hyun +8 more
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Host candidate gene polymorphisms and clearance of drug-resistant parasites [PDF]
, 2011 Resistance to anti-malarial drugs is a widespread problem for control programmes for this devastating disease. Molecular tests are available for many anti-malarial drugs and are useful tools for the surveillance of drug resistance.
Achidi, EA +21 more
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Statistical data mining for symbol associations in genomic databases
, 2013 A methodology is proposed to automatically detect significant symbol associations in genomic databases. A new statistical test is proposed to assess the significance of a group of symbols when found in several genesets of a given database.
Fournié, Jean-Jacques +2 more
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Coxiella burnetii and Leishmania Mexicana Residing Within Similar Parasitophorous Vacuoles Elicit Disparate Host Responses [PDF]
, 2015 Coxiella burnetii is a bacterium that thrives in an acidic parasitophorous vacuole (PV) derived from lysosomes. Leishmania mexicana, a eukaryote, has also independently evolved to live in a morphologically similar PV.
Cambronne, Eric D. +7 more
core +1 more source
Study of gene function based on spatial co-expression in a high-resolution mouse brain atlas [PDF]
, 2007 BACKGROUND: The Allen Brain Atlas (ABA) project systematically profiles three-dimensional high-resolution gene expression in postnatal mouse brains for thousands of genes.
Jiang, Tao +6 more
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Journal of Clinical Investigation, 2018 Epithelial tumor cells undergo epithelial-to-mesenchymal transition (EMT) to gain metastatic activity. Competing endogenous RNAs (ceRNAs) have binding sites for a common set of microRNAs (miRs) and regulate each other’s expression by sponging miRs. Here,
Xiaochao Tan +18 more
semanticscholar +1 more source
Study on the characteristics of physiological parameters and liver transcriptomes on production and methane emission during the fattening period in Japanese Black cattle [PDF]
, 2022 Tohoku University博士（農学）博士学位論文 (Thesis(doctor ...
金, 民知
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bioRxivInvestigations of the non-coding region are essential for uncovering the full spectrum of genetic drivers in melanoma. Here, we map distal, non-coding, promoter-interacting regulatory elements using Hi-C data from melanoma cells and integrating these ...
Michael Pudjihartono +3 more
semanticscholar +1 more source
Cyclic AMP signalling pathways in the regulation of uterine relaxation [PDF]
, 2007 Studying the mechanism(s) of uterine relaxation is important and will be helpful in the prevention of obstetric difficulties such as preterm labour, which remains a major cause of perinatal mortality and morbidity.
A Belmonte +63 more
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DNA methylation in genes of longevity‐regulating pathways: association with obesity and metabolic complications [PDF]
, 2019 Aging is the main risk factor for most chronic diseases. Epigenetic mechanisms, such as DNA methylation (DNAm) plays a pivotal role in the regulation of physiological responses that can vary along lifespan.
Mansego-Talavera, M.L. (María Luisa) +6 more
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