Results 161 to 170 of about 1,651,341 (263)

Feasibility study of a revised intervention for addressing student sickness absence: a qualitative evaluation. [PDF]

BMC Health Serv Res
Vanneste Y, Drost N, Neves SC, Roseval-Splinter J, Pruis M, Wind MVE, Mathijssen J.   +6 more
europepmc   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Ionomycin suppresses cancer cell growth by disrupting mitochondrial transcription

FEBS Open Bio, EarlyView.
In this study, we identify a new function for the selective Ca2+ ionophore, ionomycin, as an inhibitor of mitochondrial transcription. Both total and nascent RNA analyses revealed that ionomycin treatment reduces the transcription of mitochondrial genes.
Lishen Wang, Mingqiang Deng, Dongmei He, Diqin Lai, Dongjun Liu, Dengyong Zhu, Zhenhua Zhang, Peng Tang, Chuanman Zhou, Menghui Yin, Xichen Bao   +10 more
wiley   +1 more source

Atmospheric Degradation of Pure and Rosemary (<i>Rosmarinus officinalis</i> (L.)) Essential Oil-Added Antimicrobial Poly(Butylene Adipate-<i>co</i>-terephthalate) (PBAT) Films. [PDF]

ACS Omega
Nascimento CKS, Silva KDE, Vitorino GBL, Diniz ACO, Silva IDL, Simões AN, Souza CA, Vinhas GM, Pereira JFQ, Brito AMSS.   +9 more
europepmc   +1 more source

Dose‐dependent hepatotoxicity of hydrogen peroxide in HepG2 cells and its modulation by CYP450 induction

FEBS Open Bio, EarlyView.
NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks, Garth L. Maker, Emily C. Davies, Berin A. Boughton, Samantha Lodge   +4 more
wiley   +1 more source

How Does ACR BI-RADS^® v2025 Change the Radiologist's Approach? A Practical Guide Across Mammography, Ultrasound, and MRI: A Narrative Review. [PDF]

Diagnostics (Basel)
Kaplan E, Aydemir AB.
europepmc   +1 more source

ATZ‐1 promotes DNA replication efficiency to maintain normal meiotic function

FEBS Open Bio, EarlyView.
Absence of ATZ‐1 interferes with meiotic DNA replication and cell cycle function via CHK‐1. This causes downstream defects associated with DNA damage and genomic integrity. Taken together, this study suggests that ATZ‐1 influences DNA replication efficiency and cell cycle function to maintain normal meiotic function.
Taylin E. Gourley, Luke W. Molesworth, Nethma H. Waduge, Fahimeh Eskandari, Peter R. Boag, Gregory M. Davis   +5 more
wiley   +1 more source

Quantitation of Cirtuvivint (SM08502) in Human Plasma by LC-MS/MS. [PDF]

Biomed Chromatogr
Holleran JL, Deppas JJ, Feng Y, Hochman MJ, Chen EC, Stahl M, Gore SD, Synold TW, Beumer JH, Venkataramanan R, Parise RA.   +10 more
europepmc   +1 more source

Evaluating the effect of γ‐oryzanol on MASLD pathology using a medaka fish model

FEBS Open Bio, EarlyView.
This study explores a liver disease called MASLD, which is increasing worldwide and can lead to serious damage. Researchers used medaka fish instead of rodents to test a food compound, γ‐oryzanol. Fish fed this compound had less liver fat and healthier gut bacteria.
Yukako Ito, Haduki Asano, Ayano Ueki, Joe Sakamoto, Yasuhiro Kamei, Hayato Tokumoto, Ayaka Yazawa, Shigeki Kamitani   +7 more
wiley   +1 more source

Stable isotope labeling reveals that sugars are direct precursors to several toxicants and flavorings in cigarette smoke. [PDF]

Nicotine Tob Res
Visser WF, Klerx WNM, Cremers HWJM, Lensen DGW, Dings L, Hoving R, de Ruijter WJ, Boer K, Weibolt N, van Alphen MJ, Stepanov I, Talhout R.   +11 more
europepmc   +1 more source