Results 141 to 150 of about 7,510,835 (302)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

Molecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra, Shamsudheen Karuthedath Vellarikkal, Lixia Li, Hong Sun, Khoa Nguyen, Amber Montano, Suchitra Natarajan, Federica Piccioni, Alex Michael Tamburino, Xin Yu, Aleksandra Katarzyna Olow   +10 more
wiley   +1 more source

The Added Value of 4D-Flow CMR: Identifying Aortic Regurgitation as the Culprit for Severe Cardiomyopathy. [PDF]

Clin Case Rep
Gall A, Garg P.
europepmc   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Editorial: Multi-scale air-sea variability and its application in Indo-Pacific regions

Frontiers in Climate, 2023
Tomomichi Ogata, Takanori Horii, Hidenori Aiki, Yu-Lin K. Chang, Iskhaq Iskandar, Yukio Masumoto, Yukio Masumoto   +6 more
doaj   +1 more source

Syndromic Surveillance-Review on Different Practices' Performance and Added Value for Public Health. [PDF]

Epidemiologia (Basel)
Getsova Z, Rangelova V.
europepmc   +1 more source

Global Market Segmentation for Value-Added Agricultural Products [PDF]

International Relations/Trade,
Dooley, Frank J., Krause, Joyce Hall, Wilson, William W.   +2 more
core   +1 more source

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Alternative ankle-brachial assessments show no significant added value in predicting mortality of hypertensive patients. [PDF]

J Hypertens
Kolossváry E, Ferenci T, Járai Z, Farkas K.   +3 more
europepmc   +1 more source

The added value of multi-value QCA [PDF]

, 2013
Haesebrouck, Tim
core   +1 more source

Global Import Demand for Value-Added Wheat Products [PDF]

International Relations/Trade,
Dooley, Frank J., Krause, Joyce Hall, Wilson, William W.   +2 more
core   +1 more source