Results 161 to 170 of about 604,420 (291)

THE RELATIONSHIP BETWEEN EMOTION REGULATION DIFFICULTIES AND SOCIAL NETWORKING SITES ADDICTION

, 2023
Nasya Aurelia, Devina Anggraeni Putri Ayu Wardani A, P. Tommy Y. S. Suyasa   +2 more
openalex   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Case Study of Congklak Play Therapy for Children to Improve Social Interaction Due to Gadget Addiction

, 2021
Andan Firmansyah, Henri Setiawan, Ahmad Nizar   +2 more
openalex   +2 more sources

PICALM::MLLT10 translocated leukemia

FEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen, Antonia C. Nakatsugawa, Natalie Barton, Henry Haines, Gary S. Stein, Janet L. Stein, Daniel S. Wechsler, Jessica L. Heath   +7 more
wiley   +1 more source

The association of psychological distress and economic and health worries with tobacco smoking behavior during the COVID-19 pandemic: a two-year longitudinal cohort study

BMC Public Health
Background The COVID-19 pandemic and other life events may trigger worries and psychological distress. These impacts may lead to unhealthy behaviors, such as tobacco smoking, but the degree of such associations is unclear.
Silvia Eiken Alpers, Karl Trygve Druckrey-Fiskaaen, Tesfaye Madebo, Jørn Henrik Vold, Ståle Pallesen, Jens Christoffer Skogen, Linn-Heidi Lunde, Silje Mæland, Lars Thore Fadnes   +8 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

An Integrated Care Pathway for depression in adolescents: protocol for a Type 1 Hybrid Effectiveness-implementation, Non-randomized, Cluster Controlled Trial

BMC Psychiatry
Introduction Our group developed an Integrated Care Pathway to facilitate the delivery of evidence-based care for adolescents experiencing depression called CARIBOU-2 (Care for Adolescents who Receive Information ‘Bout OUtcomes, 2nd iteration).
Darren B. Courtney, Melanie Barwick, Bahar Amani, Andrea T. Greenblatt, Madison Aitken, Karolin R. Krause, Brendan F. Andrade, Kathryn Bennett, Kristin Cleverley, Amanda A. Uliaszek, Claire de Oliveira, Lisa D. Hawke, Jo Henderson, Wei Wang, Priya Watson, Amy Gajaria, Amanda S. Newton, Stephanie Ameis, Jacqueline Relihan, Matthew Prebeg, Sheng Chen, Peter Szatmari   +21 more
doaj   +1 more source

The Demand for NFL Attendance: A Rational Addiction Model

, 2004
Erin LeAnne Spenner, Aju J. Fenn, John R. Crooker   +2 more
openalex   +1 more source

Addictions. Substance addictions vs. behavioural addictions [PDF]

Archives of Physiotherapy and Global Researches, 2016
Jolanta Masiak, Marcin Maciejewski, Brian Wallace, Karolina Karasińska, Maja Czerniec, Dov Gal   +5 more
openaire   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source