Results 171 to 180 of about 474,753 (298)

Reflections of digital slavery in physical inactivity: examining gender-based physical activity attitudes and smartphone addiction among university students. [PDF]

Front Public Health
Altinisik U, Guler H, Isik O, Talaghir LG, Nanu L, Ivan P.   +5 more
europepmc   +1 more source

How can we conceptualize behavioural addiction without pathologizing common behaviours?

Addiction, 2017
Daniel Kardefelt-Winther, Alexandre Heeren, A. Schimmenti, A. V. Van Rooij, P. Maurage, M. Carras, J. Edman, A. Blaszczynski, Y. Khazaal, J. Billieux   +9 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

How physical activity protects against smartphone addiction: examining the mediating pathways of resilience and subjective wellbeing in Chinese university students. [PDF]

Front Psychol
Shi H, Zhang Y, Li Z, Yang J.
europepmc   +1 more source

Gender Differences in the Influence of Time Spent Online on Early Maladaptive Schemas and Life Satisfaction: Internet addiction as a mediator [PDF]

Shahla Ostovar, Reyhaneh Bagheri, Mark D. Griffiths, Leila Mohajer, Intan Hashimah Mohd Hashima   +4 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Linking Smart-Phone Addiction to Self-Concept Clarity Among Chinese College Students: The Chain Mediation Roles of Social Anxiety and Social Withdrawal. [PDF]

Inquiry
Wang X, Niu J.
europepmc   +1 more source

Late-night screen time and screen time addiction as shared determinants of poor sleep and obesity in adolescents aged 11-14 years in Scotland [PDF]

Emma Louise Gale, Andrew James Williams, Joanne E. Cecil   +2 more
openalex   +1 more source

A psychomotor stimulant theory of addiction.

Psychology Review, 1987
R. Wise, M. Bozarth
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source