Results 91 to 100 of about 5,636,748 (390)

Development of Carbon‐11 Labeled Pyrimidine Derivatives as Novel Positron Emission Tomography (PET) Agents Enabling Brain Sigma‐1 Receptor Imaging

open access: yesAdvanced Science, EarlyView.
Novel carbon‐11 labeled pyrimidine derivatives are developed as PET imaging probes for visualizing sigma‐1 receptors in the brain. [11C]CNY‐01 demonstrates superior brain uptake and binding specificity in both rodents and non‐human primates. The study reveals decreased sigma‐1 receptor expression in Alzheimer's disease, offering a promising tool for ...
Ping Bai   +12 more
wiley   +1 more source

Peningkatan Self Compassion Untuk Mereduksi Perilaku Adiktif Pengguna Sosial Media Bagi Siswa SMP

open access: yesIndonesian Journal of Learning Education and Counseling, 2020
The research aims to describe the process of counseling services on improving self-compassion of students in Surabaya Private Junior High Schools who have problems with addictive behaviors using sophisticated technology especially the social media ...
Agus Rizal   +2 more
doaj   +1 more source

SCORT–Cas13d Nanotherapy Precisely Targets the ‘Undruggable’ Transcription Factor HoxB13 in Metastatic Prostate Cancer In Vivo

open access: yesAdvanced Science, EarlyView.
SCORT–Cas13d–pre‐gHoxB13 lipid nanoparticles precisely deliver Cas13d mRNA and guide RNAs to metastatic prostate tumors in the liver, knocking down the “undruggable” transcription factor HoxB13. This approach suppresses metastatic tumor growth, extends mouse survival, and does not induce major organ toxicity or immune activation, offering a safe and ...
Zhifen Cui   +15 more
wiley   +1 more source

Types and Forms of Addictive Behavior of Law Enforcement Employees

open access: yesПсихология и право, 2019
The article discusses types and forms of an addictive behavior of law enforcement officers (in terms of employees of internal affairs bodies) in conjunction with individual psychological characteristics.
Chernyshova E.V., Suslova V.R.
doaj   +1 more source

Факторна структура опановуючої поведінки осіб з різним рівнем адиктивної ідентичності [PDF]

open access: yes, 2015
Shylina, A.A. and Gresa, N.V. (2015), “Factor structure of coping behavior of individuals with different levels of addictive identity” [“Faktorna struktura opanovuiuchoi povedinky osib z riznym rivnem adyktyvnoi identychnosti”], Pravo i Bezpeka, No. 2,
Gresa, N. V.   +3 more
core  

Behavioral addictions in addiction medicine [PDF]

open access: yes, 2016
Recent progress has been made in our understanding of nonsubstance or "behavioral" addictions, although these conditions and their most appropriate classification remain debated and the knowledge basis for understanding the pathophysiology of and treatments for these conditions includes important gaps.
Marc N. Potenza   +3 more
openaire   +3 more sources

FABP4 as a Mediator of Lipid Metabolism and Pregnant Uterine Dysfunction in Obesity

open access: yesAdvanced Science, EarlyView.
Obesity during late pregnancy contributes to uterine smooth muscle dysfunction, but the underlying mechanisms are unclear. This study identifies fatty acid binding protein 4 (FABP4) as a key player in the process, mediating excessive fatty acid uptake, lipid accumulation, and mitochondrial dysfunction in myometrial cells. FABP4 could be a novel uterine
Xuan Li   +11 more
wiley   +1 more source

A behaviour‐based coding tool for assessing supervisors' adherence and competence: Findings from a motivational interviewing implementation study

open access: yesClinical Psychology &Psychotherapy, Volume 29, Issue 6, Page 1942-1949, November/December 2022., 2022
Abstract Supervision seems to be an essential part of therapist training and thus also of implementing evidence‐based practices. However, there is a shortage of valid and reliable instruments for objective assessment of supervision competence that include both global measures and frequency counts of behaviour—two essential aspects of supervisory ...
Maria Beckman   +4 more
wiley   +1 more source

Can linking the recall system to addiction enable a better understanding of the dopaminergic pathway? [PDF]

open access: yesarXiv, 2022
Human addiction, as a learned behaviour, has and is constantly being treated psychologically, with specific and timely interventions from Neuroscience. We endorse that human addiction can receive further boost as regards treatment, when we firmly understand how it works from a quantum scale. This is majorly because the dopaminergic pathway (DP) that is
arxiv  

Clinical psychology of Internet addiction: a review of its conceptualization, prevalence, neuronal processes, and implications for treatment [PDF]

open access: yes, 2015
Research into Internet addiction (IA) has grown rapidly over the last decade. The topic has generated a great deal of debate, particularly in relation to how IA can be defined conceptually as well as the many methodological limitations.
Griffiths, MD, Kuss, DJ, Pontes, HM
core   +1 more source

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