Results 181 to 190 of about 22,700,087 (276)

Beyond the two-conformer model: boat conformers provide stereoselectivity in S_N1-type glycosylations of <i>manno</i>-type donors. [PDF]

Chem Sci
Remmerswaal WA, Hoogers D, Schoenmakers J, Bickelhaupt FM, Hansen T, Codée JDC.   +5 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ion Exchange of α‑Zirconium Phosphate Prepared by Hydrothermal Synthesis. [PDF]

ACS Omega
Hernandez C, Reynoso JL, Santiago CA, Sinclair A, Bolan SS, Mosby BM.   +5 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Charge Trap and Oxygen Barrier Engineering in Voltage-Stabilizing Grafted Silicone Rubber via Multiscale Molecular Simulations. [PDF]

Polymers (Basel)
Sun J, Zhao X, Li Z.
europepmc   +1 more source

Additional Remarks

Deutsches Ärzteblatt international, 2020
openaire   +3 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Persistence of environmental and wastewater-associated antibiotic resistance in river water. [PDF]

Environ Monit Assess
Sánchez-Cid C, Dehon E, Schweikart C, Vogel TM, Tiehm A, Stange C.   +5 more
europepmc   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Benzylidene insertion reactions in organoplatinum chemistry: mechanism and selectivity. [PDF]

RSC Adv
Moustafa ME, Boyle PD, Puddephatt RJ.
europepmc   +1 more source