Results 91 to 100 of about 644,627 (253)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Generalized (?,?)-Derivation Pada Ring Prima
, 2015 Misalkan ? adalah ring prima, ? adalah ideal dari ?, dan ? adalah suatu idempotent automorphism. Suatu additive mapping ?:?→? disebut generalized ?,? -derivation di ? yang berkaitan dengan ?,? -derivation ?:?→? jika ? ?? =? ? ? ? +? ? ? ? , untuk setiap ?
Qubatun, Ana
core
Non-additive anonymous games [PDF]
, 2008 This paper introduces a class of non-additive anonymous games where agents are assumed to be uncertain (in the sense of Knight) about opponents’ strategies and about the initial distribution over players’ characteristics in the game.
Kozhan, Roman
core
On the derivation of 𝑥ⁿ in a ring
, 1984 The main result of this paper gives conditions which ensure that an additive map of a ring R R into itself which satisfies a generalisation of the rule d x n
Douglas Bridges, Jeffrey Bergen
core +1 more source
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Generalized Derivation pada Near-ring Prima [PDF]
, 2011 Near-ring prima merupakan salah satu pengembangan dari konsep near-ring. Misalkan Nadalah near-ring, Ndikatakan near-ring prima jika aNb = 0 maka a = 0 untuk setiap a, b E N Dalam skripsi ini dibahas mengenai lemma dan teorema yang berkaitan dengan ...
Chuzaimah, Usya
core
Remarks on Generalized Derivations in Prime and Semiprime Rings
International Journal of Mathematics and Mathematical Sciences, 2010 Let R be a ring with center Z and I a nonzero ideal of R. An additive mapping F:R→R is called a generalized derivation of R if there exists a derivation d:R→R such that F(xy)=F(x)y+xd(y) for all x,y∈R.
Basudeb Dhara
doaj +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
NIL DERIVATIONS AND d-IDEALS ON POLYNOMIAL RINGS
BarekengLet be a ring. An additive mapping is called derivation if satisfies Leibniz's rule, i.e., for every In a special case, for each there exists a positive integer which depends on such that , then is called as a nil derivation on .
Ditha Lathifatul Mursyidah +3 more
doaj +1 more source