Results 241 to 250 of about 1,035,528 (296)

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

The geometry of G × E: How scaling and endogenous treatment effects shape interaction direction. [PDF]

PLoS Genet
Sadowski M, Dahl AW, Zaitlen N, Border R.   +3 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Automated modeling of population pharmacokinetic models using nlmixr2auto: a clinical trial and real-world data study

Huang Z, Fidler M, Nyang’wa B, Standing JF, Kloprogge F.   +4 more
europepmc   +1 more source

Discrete components of stress impact trajectories of childhood irritability but not adolescent mental health outcomes. [PDF]

JCPP Adv
DeSerisy M, Yang H, Cohen JW, Pagliaccio D, Herbstman JB, Peterson BS, Perera FP, Rauh V, Margolis AE.   +8 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Comparative analysis using machine learning methods for determination of pharmaceutical solubility in supercritical CO₂ considering physical properties of drugs. [PDF]

Front Med (Lausanne)
Alshahrani SM.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

A Heterogeneous Multi-Output Stacked Learning Framework for Mechanical Property Prediction of FDM-Printed ASA: Experimental Validation. [PDF]

Polymers (Basel)
Khan AH, Umar F, Ayoub U, Khan MUR, Haneef S, Siddique MF.   +5 more
europepmc   +1 more source

A Combination of <i>Psidium guajava</i> and <i>Seriphium plumosum</i> Modulates Glucose Metabolism and Reduces Hepatic GLUT2 Expression Through Additive-to-Synergistic Interactions. [PDF]

Nutrients
Thembane N, Sithole S, Hlatshwayo S, Ngubane PS, Ngcobo M, Gqaleni N.   +5 more
europepmc   +1 more source