Results 141 to 150 of about 599,677 (299)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Design parallel and sequential quantum algorithms via spectral element method on distributed quantum architectures. [PDF]

Sci Rep
Shayegan AHS.
europepmc   +1 more source

Weighted estimating equations for additive hazards models with missing covariates

Annals of the Institute of Statistical Mathematics, 2018
L. Qi, Xu Zhang, Yanqing Sun, Lu Wang, Yichuan Zhao   +4 more
semanticscholar   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source

A gene-based model of fitness and its implications for genetic variation: linkage disequilibrium. [PDF]

Genetics
Johri P, Charlesworth B.
europepmc   +1 more source

Additional file 1 of The clinical impact of estimating low-density lipoprotein cholesterol (LDL-C) using different equations in the general population

Additional file 1: Table S1. Comparison of LDL-C estimated by the Friedewald and Martin-Hopkins Equations for those participants with triglycerides < 400 mg/dL and further stratified by triglycerides < 175 and 175 < 400 mg/dL, count (%). Table S2.
Lam, Reyna, Manemann, Sheila M., Seehusen, Kristina E., Remaley, Alan T., Sauver, Jennifer L. St., Jiang, Ruoxiang, Killian, Jill M., Sampson, Maureen, Meeusen, Jeffrey W., Decker, Paul A., Roger, Véronique L., Takahashi, Paul Y., Larson, Nicholas B., Bielinski, Suzette J.   +13 more
openaire   +1 more source

Impact of a senior research thesis on students' perceptions of scientific inquiry in distinct student populations

FEBS Open Bio, EarlyView.
This study addressed how a senior research thesis is perceived by undergraduate students. It assessed students' perception of research skills, epistemological beliefs, and career goals in Biochemistry (science) and BDC (science‐business) students. Completing a thesis improved confidence in research skills, resilience, scientific identity, closed gender‐
Celeste Suart, Haley L. Zubyk, Michelle Ogrodnik, Caitlin E. Mullarkey, Felicia Vulcu   +4 more
wiley   +1 more source

Parametric optimization of graphite powder-mixed electrical discharge machining of Ni-Cr dental alloy by response surface methodology. [PDF]

Sci Rep
San ES, Özerkan HB, Subaşı M, Ayhan E, Mavi A, Salunkhe S, Nasr ESA, Čep R.   +7 more
europepmc   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

FEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso, Jaime Hiniesta‐Valero, Alejandra Guerra‐Castellano, Miguel A. De la Rosa, Irene Díaz‐Moreno   +4 more
wiley   +1 more source