Results 161 to 170 of about 315,437 (261)

Assessing the relationship between training load and injury in ultramarathon runners: a novel approach using Generalised Additive Models. [PDF]

S Afr J Sports Med
Burgess TL, Durand P, Buchholtz K.
europepmc   +1 more source

Spike-and-slab least absolute shrinkage and selection operator generalized additive models and scalable algorithms for high-dimensional data analysis. [PDF]

Stat Med, 2022
Guo B, Jaeger BC, Rahman AKMF, Long DL, Yi N.   +4 more
europepmc   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Unveiling Clutch Investment Strategies in Birds: A Case Study on Great Tits Using Generalized Additive Models. [PDF]

Ecol Evol
Socias-Martínez L, Álvarez E, Peckre LR, Barba E.   +3 more
europepmc   +1 more source

Physical Activity and Total Daily Energy Expenditure in Older US Adults: Constrained versus Additive Models. [PDF]

Med Sci Sports Exerc, 2022
Willis EA, Creasy SA, Saint-Maurice PF, Keadle SK, Pontzer H, Schoeller D, Troiano RP, Matthews CE.   +7 more
europepmc   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Exploring the association between vitamin D levels and dyslipidemia risk: insights from machine learning and generalized additive models. [PDF]

Front Nutr
Tianxiu Y, Chen Z, Yuxiang L, Xiaoyue Z, Jingyao H, Haijian G, Bei W.   +6 more
europepmc   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Time-varying reproduction number estimation: fusing compartmental models with generalized additive models. [PDF]

J R Soc Interface
Pang X, Han Y, Tressier E, Abdul Aziz N, Pellis L, House T, Hall I.   +6 more
europepmc   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source