Results 151 to 160 of about 12,996,285 (285)

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

2018 Baccalaureate Address [PDF]

, 2018
Hybel, Alex
core   +1 more source

Climate and health governance: Opportunities and challenges addressing extreme heat in the United States. [PDF]

J Clim Chang Health
Ring NL, Daley DM, Brunsell NA.
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Erratum: Work-Life Imbalance: A Challenge and an Opportunity for Neurosurgery: Corrigendum. [PDF]

Neurosurg Pract
Shitsama S, Skulsampaopol J, Saha A, Cusimano MD.   +3 more
europepmc   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Unlocking digital health: inequalities in the adoption of a patient portal. [PDF]

BMJ Health Care Inform
Barker RD, Gökmen R, Naylor D, Teo JT.
europepmc   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

26th Commencement Address [PDF]

, 1944
Burdick, E. Alverna
core   +1 more source

Developing and Assessing the Acceptability of an Information Booklet for Patients in Surveillance for Abdominal Aortic Aneurysms: An Intervention Development Study. [PDF]

Health Expect
Grindell C, Hughes J, Lumley E, Elstone A, Hall J, Michaels J, Nasim A, Radley S, Shackley P, Smith NM, Stansby G, Wood E, O'Cathain A.   +12 more
europepmc   +1 more source