Results 41 to 50 of about 86,617 (302)

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Using An Equity/Performance Matrix to Address Salary Compresion/Inversion And Performance Issues

, 2013
Pay compression and inversion are significant problems for many organizations and are often severe in schools of business in particular. At the same time, there is more insistence on showing accountability and paying employees based on performance.
Thomas, Steven L, Richardson, Peter E
core   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Inversion improves the recognition of facial expression in thatcherized images [PDF]

, 2014
The Thatcher illusion provides a compelling example of the face inversion effect. However, the marked effect of inversion in the Thatcher illusion contrasts to other studies that report only a small effect of inversion on the recognition of facial ...
Andrews, Timothy J., Andrews., Timothy J, Psalta, Lilia   +2 more
core   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Thermoelastic full-waveform inversion for joint estimation of subsurface temperature and seismic velocities in geothermal exploration

Energy Geoscience
Seismic exploration is the most precise geophysical method for investigating and forecasting subsurface resources, yet its conventional fully elastic assumption neglects temperature effects, limiting its utility in geothermal studies.
Sen Yang, Benbing Ren, Xinmin Wu, Hao Xu, Tao Yang, Yingkai Qi, Zheng Qin, Kelin Chen   +7 more
doaj   +1 more source

Molecular dynamics simulations of positively selected codons in FcγRI reveal novel biochemical binding properties

FEBS Open Bio, EarlyView.
Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young, Omar Arias‐Gaguancela, Fiona Gibson, Morgan Grainger, Jodie Score, Amit Nathubhai, Mauricio Cafiero, Lee Richard Machado   +7 more
wiley   +1 more source

Identifying seawater intrusion in coastal areas by means of 1D and quasi-2D joint inversion of TDEM and VES data

, 2017
Seawater intrusion is an increasingly widespread problem in coastal aquifers caused by climate changes –sea-level rise, extreme phenomena like flooding and droughts– and groundwater depletion near to the coastline.
Bernardo, I., C. Nascimento, Casal, Bruno, I. Bernardo, B. Casal, Nascimento, C., F.A. Monteiro-Santos, Monteiro-Santos, Fernando, Nascimento, Catarina, Ribeiro, J.A., F.J. Martínez-Moreno, Fernandes, J., J.A. Ribeiro, Martínez-Moreno, F.J., Casal, B., M. Farzamian, Martínez Moreno, Francisco José, Monteiro Santos, Fernando Acácio, Ribeiro, Joana, Farzamian, M., J. Fernandes, Farzamian, Mohammad, Bernardo, Ivo   +22 more
core   +1 more source

Reweighted regularized conjugate gradient method (RRCG) for 3D focusing inversion of potential field data

AIP Advances
Traditional objective functions in potential field inversions commonly prioritize functionals that emphasize maximal smoothness and stability. Although this approach results in petrophysical images with smooth transitions and gradients, it often fails to
Chu Jian, Wenqi Cheng, Chao Sui, Junhua Tang, Yi Hu   +4 more
doaj   +1 more source