Results 161 to 170 of about 7,378 (310)

英語における未来表現の効果的な教授法の試み 第2部: 単純未来表現においての客観的用法と修辞的用法の対比 第6~第9章 [PDF]

open access: yes, 2007
英語の未来表現を11通りのパターンに見分けた第1部に対し、第2部は、それぞれの含意が可能にする修辞的用法を中心とする考察を展開する。第6章では「どの行為者も完全な所有権を有しない、随意の行為についての予定の予告」、第7章では、「何らかのに従った結果の予告」、そして第8章では、「比較的柔軟である予定の結果の予告」を取り上げて、それぞれの表現パターンとしての効果を通じて、選択基準を明らかにしていく。最終章では、選択基準を要約し ...
Gibbs A. Stephen   +1 more
core   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

open access: yesMolecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee   +8 more
wiley   +1 more source

I and "you" in spoken discourse [PDF]

open access: yes, 2013
Contents of indexicals and how they are expressed are discussed in the present paper. Kaplan\u27s (1989) analysis of indexicals, in particular, his distinction among the utterer, the agent, and the referent of a token of "I" (Corazza et al.
Etsuko Oishi
core   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

open access: yesMolecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat   +8 more
wiley   +1 more source

An Implicature Analysis On “Oh, Brother!” Comic Strip Serials [PDF]

open access: yes, 2013
This study focuses on analyzing comic using theory of implicature and cooperative principles proposed by Grice. This study aims to (1) describe the implicatures to occur in the “Oh, Brother!” comic strip serials, (2) describe the Non observant-maxims in
, Dra. Malikatul Laela, M. Hum.   +2 more
core  

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

open access: yesMolecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley   +5 more
wiley   +1 more source

Morphological represntation of an implicative component in advertising (on English ad copy basis) [PDF]

open access: yes, 2015
У статті розглядається імплікативний компонент в текстах реклами з точки зору його морфологічної представленості. З’ясовано, що ретельно обмірковане уживання прикметників і, особливо, ступенів порівняння, займенників, прислівників, іменників, дієслів ...
Shcherbak, E., Yemelyanova, O.
core  

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova   +25 more
wiley   +1 more source

THE DISTRIBUTION OF COMMUNICATIVE PRIORITIES IN SPEECH SITUATIONS

open access: yesВестник Кемеровского государственного университета, 2015
This article was completed under the pragmatic approach and is devoted to the analysis of the hierarchy of communicative roles in speech situations.
T. A. Pivovarchyk
doaj  

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