Results 111 to 120 of about 4,194,164 (301)

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

open access: yesMolecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon   +13 more
wiley   +1 more source

Fostering an Atmosphere of Professionalism in a Residency Program: Learning How to Address the Unprofessional Behavior of Colleagues Through OSCEs

open access: yesMedEdPORTAL, 2012
Introduction Professionalism training and assessment have received much attention. Multiple strategies have been devised to help educational programs deal with unprofessional behavior, which is not always detected by attending staff.
Lita Aeder   +3 more
doaj   +1 more source

Addressing the underrepresentation of women in mathematics conferences [PDF]

open access: yes, 2015
Despite significant improvements over the last few generations, the discipline of mathematics still counts a disproportionately small number of women among its practitioners.
Martin, Greg
core  

Debiasing Desire: Addressing Bias & Discrimination on Intimate Platforms

open access: yes, 2018
Designing technical systems to be resistant to bias and discrimination represents vital new terrain for researchers, policymakers, and the anti-discrimination project more broadly.
Barocas, Solon   +3 more
core   +1 more source

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

open access: yesMolecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla   +10 more
wiley   +1 more source

Addressing the Bard: Learning Ideas [PDF]

open access: yes, 2009
The Scottish Poetry Library has published a new, provocative and exciting anthology of Burns poems, launched in the Year of Homecoming and of Burns’s 250th anniversary.
Farrell, M., Niven, L.
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RESPONSE TO ADDRESS OF WELCOME AND PRESIDENTʼS ADDRESS [PDF]

open access: yesAJN, American Journal of Nursing, 1913
n ...
openaire   +1 more source

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

open access: yesMolecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff   +11 more
wiley   +1 more source

Soil fungal communities and their impact on ginseng quality under different land use patterns

open access: yesJournal of Agriculture and Food Research
Compared to farmland soil, forest soil is considered the best soil for producing wild simulated ginseng. The main soil factors that cause differences in the quality of ginseng cultivation between forest and farmland soil are not fully understood, and ...
Zhefeng Xu   +10 more
doaj   +1 more source

Identifying Early Warning Signs: Addressing Youth Substance Use [PDF]

open access: yes, 2015
Of high school students 35 percent indicate they are current drinkers, 20 percent are binge drinkers, and 24 percent use marijuana. By the time they are seniors more than 20 percent will have used a prescription drug for a nonmedical purpose.

core  

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