Results 141 to 150 of about 2,200,099 (299)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Portrait of Lois (Lowitja) O'Donoghue addressing the National Press Club, Canberra, 1992 [picture] /
, 1992 Part of: Collection of portraits of Lois (Lowitja) O'Donoghue addressing the National Press Club, Canberra, 1992.; Title devised by cataloguer from accompanying documentation.; Also available in an electronic version via the Internet at: http://nla.gov ...
Seselja, Loui, 1948-
core
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Addressing gender inequality issues in Australia: An annual review of developments
Addressing issues of gender inequality is ongoing and important in the context of broader employment relations at work. Scholars within the Australian industrial relations community work toward the continuance of research and analysis that highlights the
Ressia, Susan
core +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
Discussion on Psychology Graduate Leading to its Curricular Addressing
Psicologia, 1999 Although the revision and updating process on psychology graduation has endured some decades in Brazil, it seems to be nearing its end.
Armando Rocha Junior
doaj
Addressing the Address Books' (Interdependent) Privacy Issues
Interdependent privacy (IDP), which refers to situations where individuals affect the privacy of others, is a growing concern and has been studied in various contexts. Digital address books (DABs), where users store personal information about others on online services, are a compelling yet understudied case of IDP.
Tamò-Larrieux, Aurelia +7 more
openaire +4 more sources