Results 41 to 50 of about 1,170,430 (263)

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

open access: yesTherapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin   +2 more
wiley   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

Byte Addressing Mode Expansion and 64bit Data Operation Simulation Implementation for BWDSP104X [PDF]

open access: yesJisuanji gongcheng, 2016
Currently,the programming model under BWDSP104X compiler is based on the word unit addressing modes,lacking of support for non 32-bit wide data and incompatible with byte unit addressing modes.With the modification of related frontend data type,the ...
ZHAO Gaoyi,ZHENG Qilong
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Prospects of addressing the challenges of gender inequalities in Christian missions

open access: yesHTS Teologiese Studies/Theological Studies
Gender inequality has been pervasive in many aspects of society, including religious institutions. Christian missions often reinforce patriarchal structures that limit the participation of women in leadership and ministry roles.
Akinyemi O. Alawode
doaj   +1 more source

ADDRESS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1895
n ...
openaire   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

ADDRESS. [PDF]

open access: yesJAMA: The Journal of the American Medical Association, 1898
n ...
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Communicative-Pragmatic Properties of Addressing in Virtual Pedagogical Discourse: Insights from School Chats

open access: yesНаучный диалог
This study explores the communicative-pragmatic properties of addressing as a syntactic phenomenon manifested within virtual pedagogical discourse. The relevance ofthis topic is underscored by its integration into the scientific paradigm of discourse ...
T. G. Rabenko   +2 more
doaj   +1 more source

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