Results 251 to 260 of about 644,554 (330)

Leishmania donovani's protein tyrosine phosphatases interact with DUF21 and respond to environmental magnesium

The FEBS Journal, EarlyView.
The Leishmania phosphatase PTP1, and possibly the genetically similar PTP2, interacts with the Leishmania transmembrane protein DUF21. When both ptp1 and ptp2 are knocked out of Leishmania (LdΔPTP1/2), the parasite can no longer survive without magnesium in vitro and has reduced viability in the host macrophage. Conversely, in duf21 knockout (LdΔDUF21),
Kayla Paulini, Hira Khursheed, Wen Wei Zhang, Isabelle Aubry, Greg Matlashewski, Michel L. Tremblay, Patrick Lypaczewski   +6 more
wiley   +1 more source

Natural occurrence of drug resistance mutations to the HIV‐1 capsid inhibitor lenacapavir

HIV Medicine, EarlyView.
Abstract Aims Lenacapavir (LEN) is a first‐in‐class HIV‐1 capsid inhibitor. We investigated the natural occurrence of LEN drug resistance mutations (DRM) in HIV‐1 sequences from LEN treatment‐naïve individuals. Methods We analysed all available HIV‐1 capsid sequences (n = 21 646) from individuals never exposed to LEN from the Los Alamos National ...
A. Weibull Wärnberg, R. Ceña‐Diez, A. Sönnerborg, M. A. A. van de Klundert   +3 more
wiley   +1 more source

Targeting mitochondrial transporters and metabolic reprogramming for disease treatment. [PDF]

J Transl Med
Anselme M, He H, Lai C, Luo W, Zhong S.
europepmc   +1 more source

Spatial Transcriptomic Assessments of Gene Expression Profiles in Human Peri‐Implant Lesions

Journal of Clinical Periodontology, EarlyView.
ABSTRACT Aim To analyse gene expression profiles in human tissue samples obtained from dental implant sites with or without peri‐implantitis. Materials and Methods Soft‐tissue biopsy samples obtained from patients presenting with implants with severe peri‐implantitis and adjacent reference implants with no signs of peri‐implantitis were analysed by ...
C. Dionigi, A. C. Ericson, A. Shikhan, L. Larsson, T. Berglundh   +4 more
wiley   +1 more source

Structure-guided engineering of a polyphosphate kinase 2 class III from an <i>Erysipelotrichaceae</i> bacterium to produce base-modified purine nucleotides. [PDF]

RSC Chem Biol
Mitton-Fry RM, Rasche R, Lawrence-Dörner AM, Eschenbach J, Tekath A, Rentmeister A, Kümmel D, Cornelissen NV.   +7 more
europepmc   +1 more source

Expression of corticoid‐regulatory genes in the gills of Atlantic salmon (Salmo salar) parr and smolt and during salinity acclimation

Journal of Fish Biology, EarlyView.
Abstract In teleost fishes, cortisol is the major corticoid and has both glucocorticoid and mineralocorticoid actions. However, how fish tissues discriminate between these distinct corticosteroid actions is unclear. In mammals, the major factors responsible for intracellular corticosteroid regulation are glucocorticoid receptors (grs) and the ...
Makoto Kusakabe, Takashi Yada, Graham Young, Amy M. Regish, Stephen D. McCormick   +4 more
wiley   +1 more source

Cardiomyocyte-Specific Deletion of Sirtuin 5 Accelerates the Development of Heart Failure Upon Dysregulating Purine Metabolism. [PDF]

Acta Physiol (Oxf)
Byrne NJ, Koentges C, Pfeil K, Lueg JC, Bakshi S, Tarkhnishvili A, Vosko I, Gollmer J, Birkle LC, Rathner T, Birkle S, Tang S, Rau C, Hoffmann MM, Odening KE, Barnes S, Wilson LS, Ljubojevic-Holzer S, Wallner M, von Lewinski D, Rainer P, Sedej S, Sourij H, Bode C, Wende AR, Zirlik A, Bugger H.   +26 more
europepmc   +1 more source

Systemic, Lifestyle and Environmental Modifying Factors in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
A variety of impacting factors in the pathogenesis of periodontitis exist, including systemic, lifestyle, and environmental factors. This review highlights the manifold mechanistic aspects of the link between the pathogenesis of periodontitis, addressing these numerous factors to supplement the long‐standing knowledge of the progression of the disease.
Groeger Sabine Elisabeth, Zhou Yuxi, Yong Jiawen, Wang Lei, Ruf Sabine, Meyle Joerg   +5 more
wiley   +1 more source

Engineering Adenine Deaminase TadA for Precise and PAM-Flexible Point Mutagenesis and Gradient-Tuning Endogenous Protein Design. [PDF]

Adv Sci (Weinh)
Sun K, Cheng S, Chai N, Mi J, Zhang R, Qian Q, Zheng Z, Chen K, Zeng D, Peng X, Shen M, Zhou D, Zhu Q, Liu Q, Tan J.   +14 more
europepmc   +1 more source

Targeted Deletion of the Cytopathogenic Toxin A Gene in Sneathia vaginalis

Molecular Microbiology, EarlyView.
Sneathia vaginalis is emerging as an important marker for preterm birth. Through this study, we developed a method for site‐directed mutagenesis in this species. The gene encoding the cytopathogenic toxin A (CptA) was deleted as a proof of principle, and the deletion mutant revealed that CptA is indispensable for the cytotoxic and hemolytic activities ...
Rishi M. Ray, Phoebe V. Bridy, Aubree G. Musicant, Shiny Chandravel, Youstina Y. Aziz, Jasmine C. Cruz, Kimberly K. Jefferson   +6 more
wiley   +1 more source