Results 291 to 300 of about 823,307 (385)

Distinct CTC Specific RNA Profile Enables NSCLC Early Detection and Dynamic Monitoring of Advanced NSCLC

Advanced Science, EarlyView.
A quantitative CTC RNA assay is developed by incorporating multi‐antibody‐based CTC isolation and specific mRNA quantification using RT‐ddPCR. The NSCLC CTC ScoreD demonstrates high accuracy for early‐stage NSCLC detection, significantly outperforming serum CEA. NSCLC CTC ScoreM exhibits a more accurate early‐warning of responses to different therapies
Xiaoyu Wang, Pi Ding, Wenjuan Xu, Lei Qiu, Jing Ren, Yucheng Fei, Zhili Wang, Cheng Li, Yufei Xing, Mingjing Shen, Yawen Zhu, Yun Guo, Na Sun, Renjun Pei, Minhua Shi   +14 more
wiley   +1 more source

Primary Adenocarcinoma of the Upper Urinary Tract: A Systematic Review of the Literature on a Rare Entity. [PDF]

J Clin Med
Giannakodimos I, Bekiaris E, Ziogou A, Giannakodimos A, Mitakidi E, Psalla K, Fragkiadis E, Kaltsas A, Kratiras Z, Chrisofos M.   +9 more
europepmc   +1 more source

STING Agonists and How to Reach Their Full Potential in Cancer Immunotherapy

Advanced Science, EarlyView.
STING agonists show promise in preclinical studies in boosting an anti‐tumor response using the immune system. However, different limitations remain, and future research is needed to better understand how STING activation impacts the tumor microenvironment, identify effective combination strategies, and determine the best tumor types for STING agonist ...
Laura Gehrcken, Christophe Deben, Evelien Smits, Jonas R.M. Van Audenaerde   +3 more
wiley   +1 more source

Study on the efficacy of IFN-γ- and sPD-1-overexpressing BMSCs in enhancing immune effects for the treatment of lung adenocarcinoma. [PDF]

Front Immunol
Xie Y, Lv Z, Wang Y, Ma J, Wei X, Zheng G, Wu J.   +6 more
europepmc   +1 more source

MAGEA6 Engages a YY1‐Dependent Transcription to Dictate Perineural Invasion in Colorectal Cancer

Advanced Science, EarlyView.
This study investigates the role of MAGEA6 in perineural invasion (PNI) in colorectal cancer (CRC). MAGEA6 promotes CRC invasiveness by inhibiting YY1 ubiquitination, enhancing CXCL1 secretion, and recruiting Schwann cells. These findings highlight the potential of targeting the MAGEA6/YY1/CXCL1 axis for therapeutic strategies against PNI and tumor ...
Hao Wang, Kexin He, Ruixue Huo, Weihan Li, Shan Zhang, Lu‐Ju Jiang, Hao Wu, Minhao Yu, Shu‐Heng Jiang, Junli Xue   +9 more
wiley   +1 more source

Duodenal Bulb Adenocarcinoma: A Case Report. [PDF]

Cureus
Kloub MN, Abusalim AI, Farouji A, Eldesouki M, Anwar A, Atiyat R, Shah M.   +6 more
europepmc   +1 more source

IFITM2 Modulates Endocytosis Maintaining Neural Stem Cells in Developing Neocortex

Advanced Science, EarlyView.
This study reveals IFITM2 as a key regulator of endocytosis in radial glial cells (RGCs) during brain development. IFITM2's YXXø motif and phosphoinositide‐binding residues (K82/K87) are essential for endosome formation. IFITM2 deficiency disrupts the embryonic cortical neurogenesis, revealing a conserved mechanism linking endocytic dynamics to neural ...
Yuqing Lv, Wenzheng Zou, Lin Li, Shukui Zhang, Jiaqi Liang, Jiali Pu, Jianwei Jiao   +6 more
wiley   +1 more source

CT83 Promotes Cancer Progression by Upregulation of PDL1 in Adenocarcinoma of the Cervix. [PDF]

Int J Mol Sci
Kim G, Lee KJ, Shin E, Park ST, Kim HS, Cho HY.   +5 more
europepmc   +1 more source

Methionine Metabolism Dictates PCSK9 Expression and Antitumor Potency of PD‐1 Blockade in MSS Colorectal Cancer

Advanced Science, EarlyView.
xxxx. Abstract Nutrient metabolisms are vitally interrelated to cancer progression and immunotherapy. However, the mechanisms by which nutrient metabolisms interact to remodel immune surveillance within the tumor microenvironment remain largely unexplored.
Qi‐Long Wang, Zijie Chen, Xiaofei Lu, Huizhen Lin, Huolun Feng, Nuozhou Weng, Liwen Chen, Mengnan Liu, Li Long, Lingjun Huang, Yongmei Deng, Kehong Zheng, Xiaojun Zheng, Yong Li, Ting Cai, Jiabin Zheng, Wei Yang   +16 more
wiley   +1 more source

Molecular characterization of early-stage lung adenocarcinoma presenting as subsolid nodules in a real-life European cohort. [PDF]

BMC Cancer
Tajè R, Gallina FT, Caterino M, Forcella D, Patirelis A, Alessandrini G, Buglioni S, Cecere FL, Fusco F, Cappelli F, Melis E, Visca P, Cappuzzo F, Ambrogi V, Vidiri A.   +14 more
europepmc   +1 more source