Results 301 to 310 of about 238,585 (333)
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Immunohistochemistry of Adenosine Deaminase: Implications for Adenosine Neurotransmission
Science, 1984Immunohistochemical analysis of adenosine deaminase in rat brain revealed an extensive plexus of adenosine deaminase-containing neurons in the basal hypothalamus. These neurons converged on and were most numerous in three major centers, namely, the tuberal, caudal, and postmammillary caudal magnocellular nuclei.
M. Buss +3 more
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1977
Publisher Summary Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Antonio Lucacchini +2 more
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Publisher Summary Adenosine deaminase plays a key role in adenosine metabolism. This nueleoside has some important pharmacological and toxic effects. An adenosine deaminase deficiency observed in some cases of severe congenital immunodeficiency represents the first link between an immunological and enzymic defect.
Antonio Lucacchini +2 more
openaire +2 more sources
The linkage relationships of adenosine deaminase
Annals of Human Genetics, 1970SUMMARYThe lod scores for seventy‐six families segregating for adenosine deaminase have been estimated. Taken in conjunction with other published lod scores there is a suggestion that ADA may be linked with P.
D. A. Hopkinson +2 more
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Adenosine deaminase isozymes in Artemia
Comparative Biochemistry and Physiology Part B: Comparative Biochemistry, 1984Three isozymes of adenosine deaminase, termed II, III and IV, have been detected in Artemia embryos. Their pI values, determined by chromatofocusing, were 4.9, 5.0 and 5.2, respectively. Upon development to larvae, a different isozyme (I) is induced, with a pI value of 4.2 as determined by isoelectric focusing.
Angeles Faraldo +5 more
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Treatment of Adenosine Deaminase Deficiency
BioDrugs, 1998Severe combined immune deficiency disease due to a deficiency of the enzyme adenosine deaminase is a rare disease. However, it has been used as a prototype disease for the development of a variety of treatment modalities that are currently applied in more frequent diseases.
Jack J.H. Bleesing +3 more
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Specificity of adenosine deaminase inhibitors
Biochemical Pharmacology, 1977Abstract The specificity of the potent adenosine deaminase inhibitors deoxycoformycin (covidarabine), coformycin and erythro -9-(2-hydroxy-3-nonyl)adenine (EHNA), has been assessed in Ehrlich ascites tumor cells in vitro and in cultured mouse lymphoma L5178Y cells.
J. Frank Henderson +4 more
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Effect of adenosine deaminase on cardiac interstitial adenosine
American Journal of Physiology-Heart and Circulatory Physiology, 1992Adenosine deaminase was infused into isolated perfused guinea pig hearts to determine its effect on myocardial adenosine levels. The enzyme was administered during constant coronary flow perfusion at 6.11 +/- 0.36 ml.min-1.g-1. Venous adenosine was measured in samples of pulmonary artery effluent; epicardial and endocardial adenosine were measured ...
Robert M. Berne +4 more
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Study on the inhibition of adenosine deaminase
Journal of Medicinal Chemistry, 1985AbstractDas Ribofuranosylimidazol (IV) erhält man durch Umsetzung von (II) mit(III) und anschließende Folgereaktio‐ nen; es ist weitaus geringer aktiv als der Adenosindesaminase‐Inhibitor Coformycin ′ (I).
H. J. Thomas +4 more
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The roles of adenosine deaminase in autoimmune diseases.
Autoimmunity Reviews, 2020Zhao-Wei Gao +5 more
semanticscholar +1 more source