Results 191 to 200 of about 253,092 (356)

A DETAILED PROCEDURE FOR THE PREPARATION OF HIGHLY PURIFIED ADENOSINE TRIPHOSPHATE

open access: hybrid, 1948
Alexander L. Dounce   +4 more
openalex   +1 more source

Pyruvate Kinase Function Correlates With Red Blood Cell Properties and Clinical Manifestations in Sickle Cell Disease

open access: yesAmerican Journal of Hematology, Volume 100, Issue 5, Page 785-796, May 2025.
ABSTRACT Pyruvate kinase (PK) is a key enzyme involved in the final step of glycolysis, essential to produce adenosine triphosphate (ATP). Relatively decreased red blood cell (RBC) PK activity (reflected by a lower PK/hexokinase [HK] ratio) and PK thermostability (PK activity after exposure to heat) were recently identified as pathophysiological ...
M. J. M. Traets   +17 more
wiley   +1 more source

Case Report: Unusual Neurological Features of Leigh Syndrome due to m.8993T>G Pathogenic Variant in the MT‐ATP6 Gene

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT The MT‐ATP6 gene m.8993T>G pathogenic variant has been associated with Leigh syndrome, especially in patients exhibiting a high degree of heteroplasmy. Although patients may present with a wide phenotypic spectrum, characteristic findings include bilateral, symmetric hyperintensities in the basal ganglia and brainstem on brain MRI ...
Ramya Treitel   +2 more
wiley   +1 more source

Oral ATP treatment in alternating hemiplegia of childhood: a case report and review

open access: yesFrontiers in Medicine
Alternating hemiplegia of childhood (AHC) is a rare neurological disorder that usually manifests before 18 months of age and is characterized by recurrent, alternating episodes of hemiparesis with variable frequency and can last from a few minutes to ...
Marco Carrozzi   +13 more
doaj   +1 more source

In vivo toxic and lethal cardiorespiratory effects of a synthetic quaternary ammonium salt derivative of haloperidol in mice

open access: yesAnimal Models and Experimental Medicine, EarlyView.
Hematoxylin–eosin (H&E) stains of the heart, liver, lung, and kidney show acute toxicity. Abstract Background To investigate the toxicity of N‐n‐butyl haloperidol iodide (F2), a quaternary ammonium salt derivative of haloperidol, in mice for potential therapeutic purposes. Methods The acute median lethal dose (LD50) of F2 was determined using the Bliss
Jilin Liao   +6 more
wiley   +1 more source

Adenosine triphosphate (ATP) as a possible indicator of extraterrestrial biology [PDF]

open access: yes
The ubiquity of adenosine triphosphate (ATP) in terrestrial organisms provides the basis for proposing the assay of this vital metabolic intermediate for detecting extraterrestrial biological activity.
Chappelle, E. W., Picciolo, G. L.
core   +1 more source

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