Results 161 to 170 of about 172,301 (236)

Inflammatory Mediation of the Association Between Latent Clinical Phenotypes and Multidimensional Outcomes in Pediatric Community-Acquired Pneumonia. [PDF]

J Inflamm Res
Wang J, Chen L, Mao S.
europepmc   +1 more source

Enterovirus infections in children

Pediatric Investigation, EarlyView.
Enteroviruses (EVs) are major pathogens causing a wide spectrum of diseases in children worldwide. This review summarizes the epidemiology, virology, viral replication, and virus‐host interactions of EVs. It also highlights current advances in clinical diagnosis, antiviral therapies, and vaccine development, providing insights into future strategies ...
Xiangpeng Chen, Lingyun Guo, Xiaobo Lei, Linqing Zhao, Mingyan Hei, Jun Shen, Ju Yin, Fei Li, Jikui Deng, Gang Liu, Yong Zhang, Zhengde Xie   +11 more
wiley   +1 more source

Hypoxia increases the activity of oncolytic adenoviruses through HIF-2α-stimulated E1A expression. [PDF]

Signal Transduct Target Ther
Jacobus EJ, Lafleur VN, Fisher KD, Mole DR, Seymour LW.   +4 more
europepmc   +1 more source

National Burden of Human Adenovirus Infections in China: A Community-Based Multiplier Modeling Study. [PDF]

J Med Virol
Feng Q, Dai A, Zhou X, Ma L, Zhang H, Qu R, Chen M, Chen J, Miao J, Qi J, Zhou W, Yao L, Cen M, Chen Z, Chen C, Zhou J, Yang S.   +16 more
europepmc   +1 more source

Precision immunomodulation for pediatric hemophagocytic lymphohistiocytosis in intensive care

Pediatric Investigation, EarlyView.
This review presents a bedside framework for recognizing pediatric hemophagocytic lymphohistiocytosis and cytokine storm, stabilizing organ dysfunction, identifying the underlying phenotype, selecting targeted immunomodulation, considering extracorporeal adjuncts, and reassessing response within 24–72 h. ABSTRACT Hemophagocytic lymphohistiocytosis (HLH)
Weerapong Lilitwat, Prakreeti Bhandari
wiley   +1 more source

Interpretable machine learning identifies a clinically inferred inflammasome-associated inflammatory injury phenotype in children with adenovirus pneumonia. [PDF]

Front Cell Infect Microbiol
Li J, Wu Y, Huang Y, Deng W.
europepmc   +1 more source

Spatiotemporal distribution of Escherichia coli and fecal and non-fecal pathogens in the urban surface water system of Amsterdam. [PDF]

Environ Monit Assess
Gao S, Wagner T, van der Wielen P, Rijnaarts H, Șișcanu N, Sutton N.   +5 more
europepmc   +1 more source

A Multiple‐Model‐Informed Drug‐Development Approach for Optimal Regimen Selection of an Oncolytic Virus in Combination With Pembrolizumab

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 572-582, March 2025.
ABSTRACT The antitumor efficacy of an intratumoral injection of a genetically engineered oncolytic vaccinia virus carrying human IL‐7 and murine IL‐12 genes (hIL‐7/mIL‐12‐VV) was demonstrated in CT26.WT‐bearing mice. In the CT26.WT‐bearing mouse model, the efficacy of the combination of hIL‐7/mIL‐12‐VV plus the anti‐programmed cell death protein (PD)‐1
Akihiro Yamada, Mary P. Choules, Frances A. Brightman, Shigeru Takeshita, Shinsuke Nakao, Nobuaki Amino, Takeshi Nakayama, Masato Takeuchi, Kanji Komatsu, Fernando Ortega, Hitesh Mistry, David Orrell, Christophe Chassagnole, Peter L. Bonate   +13 more
wiley   +1 more source

Complete genome sequence of two skunk adenovirus strains identified in African pygmy hedgehogs in Germany. [PDF]

Microbiol Resour Announc
Morito HLE, Jesse ST, Runft S, Puff C, Baumgärtner W, Osterhaus ADME, Ludlow M.   +6 more
europepmc   +1 more source

Cordycepin Alleviates Non Alcoholic Fatty Liver Disease Progression by Stabilizing GCH1 to Inhibit Ferroptosis

Phytotherapy Research, EarlyView.
COR stabilizes GCH1 and inhibits ferroptosis. ABSTRACT To investigate the effects and targets of cordycepin (COR) in alleviating non‐alcoholic fatty liver disease (NAFLD). High‐fat diet was used to induce NAFLD in mice, and after COR gavage administration, changes in liver function, glucose and lipid metabolism, and ferroptosis‐related signaling were ...
Chenyang Han, Jian Sheng, Hongyan Pei, Wenyan Li, Shasha Wu, Yi Yang, Chenxi Cao, Zhiling Tang   +7 more
wiley   +1 more source