Results 211 to 220 of about 172,301 (236)

Adenovirus infection associated with focal segmental glomerulosclerosis following autologous hematopoietic stem cell transplantation. [PDF]

CEN Case Rep
Arana-Escandón YI, Ramírez-Arboleda PE, Gaviria-Jaramillo LM, Álzate-Arias MA, Perilla-Suarez OG, Lagos-Buitrago MX, Rodelo-Ceballos JR, Estacio MA, Taborda-Murillo A.   +8 more
europepmc   +1 more source

Targeting PCSK9 in Vascular Smooth Muscle Cells: An Effective Strategy to Suppress Ferroptosis and Attenuate Abdominal Aortic Aneurysm Progression

Cell Proliferation, EarlyView.
PCSK9 aggravates AAA by promoting ferroptosis in VSMCs. In the pathological AAA environment, PCSK9 upregulation triggers ferritinophagy‐dependent degradation of FTH1, leading to Fe2+ release, triggering lipid peroxidation and ferroptosis, exacerbating AAA.
Mengdie Xia, Man Li, Yanyu Chen, Jialin Chen, Yuting Cui, Xi‐Long Zheng, Jing Yang, Bingzhao Li, Xiaofeng Ma, Miao Liu, Gang Fan, Juan Peng, Xiaoyan Dai, Zhihan Tang   +13 more
wiley   +1 more source

A 3-year wastewater-based epidemiology study of noroviruses in Senegal. [PDF]

Appl Environ Microbiol
Diaw N, Boussiengui GL, Ndiaye N, Barry MA, Kébé O, Dia N, Faye O, Faye M.   +7 more
europepmc   +1 more source

PLIN5 Protects Against Ang II‐Induced Podocyte Lipotoxicity by Interacting With FKBP8 and Preserving Lipid Droplet–Mitochondria Contact

Cell Proliferation, EarlyView.
PLIN5‐FKBP8 tethers lipid droplets to mitochondria to counteract Ang II‐induced lipotoxicity. ABSTRACT Chronic kidney disease (CKD) remains a major global health challenge. Angiotensin II (Ang II)‐induced lipotoxicity is an important contributor to podocyte injury.
Ping Wang, Wenjie Chen, Jingjing Ke, Hongtu Hu, Zhuan Peng, Yue Qi, Guohua Ding, Jijia Hu   +7 more
wiley   +1 more source

Oncolytic viruses in head and neck cancer: therapeutic promise and translational challenges. [PDF]

Front Immunol
Wang H, Shen H, Zhang M, Mou Y, Ren C, Sun Y, Liu W, Sun C, Li D, Li Y, Qu P, Song X.   +11 more
europepmc   +1 more source

Ammonia Accumulation Drives Intervertebral Disc Degeneration by Triggering Ammonia‐Induced Cell Death Through Lysosome–Mitochondria Crosstalk

Cell Proliferation, EarlyView.
Mechanical strain disrupts the lysosome‐mitochondria axis via GLS1‐mediated ammonia toxicity, causing NP cell death and ECM breakdown in IVDD. CB839‐mediated GLS1 inhibition effectively rescues cellular homeostasis and alleviates disc degeneration.
Yang Zhang, Yucheng Gao, Shuhang Dong, Shuanggong Liu, Lei Liu, Ziyi Song, Jie Xu, Yijun Rong, Guangxu Song, Yingze Zhang, Dongjin Wu, Zengxin Gao   +11 more
wiley   +1 more source

Evaluation of false positive enteric viruses results from the BIOFIRE® FILMARRAY® gastrointestinal PCR panel. [PDF]

J Clin Virol
Chhabra P, Cates J, Bartlett E, Embury SA, Rizwan A, Williams FA, Kambhampati AK, Marconi VC, Epstein L, Jasarevic R, Kraft CS, Rodriguez-Barradas MC, Morones RG, Covarrubias MA, Beenhouwer DO, Goldin E, Brown ST, Pena I, Lucero-Obusan CA, Holodniy M, Gautam R, Mirza SA, Vinjé J, Surveillance Platform for Enteric and Respiratory Infectious Organisms at the VA (SUPERNOVA) AGE Surveillance Group.   +23 more
europepmc   +1 more source

A guide to transcriptional cyclin‐dependent kinases in cancer

The FEBS Journal, EarlyView.
Transcriptional cyclin‐dependent‐kinases (tCDKs) facilitate gene expression by promoting RNA polymerase II (RNAPII) progression through discrete phases of the transcription cycle. Aberrant tCDK activity is detectable in different human cancers, thereby contributing to de‐regulated gene expression programs that drive oncogenic phenotypes.
Jennifer R. Devlin, Salla Kyheröinen, Ricky W. Johnstone   +2 more
wiley   +1 more source

Recombinant human adenovirus type 5-vectored vaccine expressing avian reovirus σC protein protects against prevalent genotype I avian reovirus in chickens. [PDF]

Poult Sci
Cui X, Song Z, Zhou D, Yang L, Chen H, Zhang H, Cheng Z.   +6 more
europepmc   +1 more source

USP30 inhibits wound healing in diabetic foot ulcers by promoting TRAF6‐induced ferroptosis and angiogenesis inhibition

Journal of Diabetes Investigation, EarlyView.
High glucose upregulates USP30 in HUVECs, which deubiquitinates and stabilizes TRAF6. Stabilized TRAF6 suppresses GPX4 and SLC7A11, increases ROS/MDA/lipid peroxidation, and activates ferroptosis and apoptosis, leading to impaired angiogenesis and delayed wound healing.
Jingjing Yuan, Shuang Sui, Zhenghua Yang, Kaiwen Zhang, Qiang Hu   +4 more
wiley   +1 more source