Results 251 to 260 of about 193,080 (304)

Retinoic Acid‐Related Orphan Nuclear Receptor Alpha Promotes Cartilage Degeneration in Osteoarthritis by Activating the Wnt/β‐Catenin Pathway

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
During the development of OA, elevated RORα in chondrocytes inhibits β‐catenin degradation in the cytoplasm by activating the Wnt/β‐catenin signaling pathway. When β‐catenin protein accumulates excessively in the cytoplasm, it is transferred to the nucleus and binds to the cytosolic TCF/LEF transcriptional complex, which activates downstream target ...
Ruijue Zhu, Tianwei He, Jiawei Di, Lang Mai, Depeng Wu, Mudan Huang, Yankui Liu, Zhongyu Liu, Liangming Zhang, Lei He   +9 more
wiley   +1 more source

Epidemiology of respiratory infectious diseases after the relaxation of COVID-19 policies: a retrospective study in Xiamen, China. [PDF]

Front Public Health
Qu L, Jing X, Wang R, Zhang K, Su M, Lian L, Yang C, Wang H.   +7 more
europepmc   +1 more source

Reduced Maintenance DNA Methylation Thresholds Enable Sensitive Reporter Assays for UHRF1 and DNMT1 Inhibition

Advanced Science, Volume 13, Issue 32, 9 June 2026.
The authors engineer colorectal cancer cells with reduced redundancy of UHRF1 and DNMT1, key DNA methylation maintenance factors, lowering the maintenance threshold and sensitizing cells to inhibition. They develop reporter assays driven by endogenous tumor‐suppressor gene promoters with enhanced sensitivity and dynamic range to demethylating drugs ...
Cuicui Xia, Ying Cui, Jiongliang Wang, Wenjing Bai, Danyang Wang, Yao Chen, Huahui Guo, Liangyi Zong, Bing Qin, Xintong Cai, Jie Wang, Jing Huang, Scott B. Rothbart, Zufeng Guo, Stephen B. Baylin, Xiangqian Kong   +15 more
wiley   +1 more source

Establishment of a Sensitized 3D Spheroid Cancer Cell Model for Enhanced Anti-Cancer Drug Discovery. [PDF]

Methods Protoc
Tan EW, Goh TY, Law SH, Tan KO, Goh BH.
europepmc   +1 more source

Integrating Oncolytic Virus Engineering and Delivery Strategies for Enhanced Cancer Virotherapy

Aggregate, Volume 7, Issue 6, June 2026.
Integrated engineering strategies combining oncolytic virus (OV) design with advanced delivery platforms overcome biological barriers and enhance cancer virotherapy. Genetic engineering improves viral potency and selectivity, while local and systemic delivery systems promote viral protection, tumor targeting, penetration, and tumor microenvironment ...
Jiliang Zhao, Dong Wang, Lei Wang, Hongkai Zhang, Yue Sun, Dan Ding   +5 more
wiley   +1 more source

Adenovirus-Associated Opsoclonus After Allogeneic Hematopoietic Stem Cell Transplantation. [PDF]

EJHaem
Miyajima T, Hoshino S, Nojima S, Shiratori S, Iwanami T, Teshima T.   +5 more
europepmc   +1 more source

Beyond Rotavirus: Persistence of Norovirus, Adenovirus, and Astrovirus in Paediatric Gastroenteritis in the Republic of Congo After Vaccine Introduction. [PDF]

J Med Virol
Mboungou CLD, Mapanguy CCM, Anh DD, Vouvoungui JC, Mouanga AM, Louya VM, Kupoluyi ES, Ampa R, Velavan TP, Ntoumi F.   +9 more
europepmc   +1 more source

‘BJUI Clinical Dilemma’: Recurrent high‐grade non‐muscle‐invasive bladder cancer in 2026

BJU International, Volume 138, Issue 1, Page 14-21, July 2026.
Vignesh T. Packiam, Peter C. Black, James W. F. Catto, Saum Ghodoussipour, Max Kates, Ashish M. Kamat, Yair Lotan, Michael A. O’Donnell, Jeremy Y. C. Teoh, George N. Thalmann, Stephen B. Williams   +10 more
wiley   +1 more source

Fire in an Icy Desert: Oncolytic Virotherapy for Pancreatic Adenocarcinoma. [PDF]

Pharmaceutics
Rossetto A, Reale A.
europepmc   +1 more source

HAdV55 reprograms host 3D genome architecture and mitochondrial metabolism to drive pathogenesis. [PDF]

Cell Mol Life Sci
Wang K, Li J, Chen Z, Wang N, Li D, Hong H, Liu X, Lin Y, Chen Q, Li P, Yang L, Jia L, Pan H, Jiang Y, Li P, Song H.   +15 more
europepmc   +1 more source