Results 211 to 220 of about 113,140 (295)

An intracellular recombinant single‐chain variable antibody fragment as a new class of phosphodiesterase type 5 inhibitors

British Journal of Pharmacology, EarlyView.
Background and Purpose Cyclic guanosine monophosphate (cGMP) is a ubiquitous second messenger involved in human (patho‐)physiology. Phosphodiesterase 5 (PDE5) is a major cGMP hydrolyzing enzyme in many cell types including vascular smooth muscle cells (VSMCs). Several highly selective PDE5 inhibitors are in clinical use. However, there are currently no
Kürsat Kirkgöz, Sophie Sprenger, Olga Schweigert, Sanika Mohagaonkar, Matti Walsdorff, Tanja Zeller, Filip Berisha, Viacheslav O. Nikolaev, Sergei D. Rybalkin   +8 more
wiley   +1 more source

Coordinated antiviral immune response in a patient with myeloma and systemic adenovirus infection post-BCMA CAR T cells. [PDF]

Blood Adv
Kocoglu MH, Luetkens T, Bork JT, Baddley J, Omili D, Gebru E, Mulatu R, Yamoah D, Iraguha T, Fan X, Lesho P, Yousaf M, Baker JM, Dietze KA, Hankey KG, Badros A, Yared JA, Rapoport AP, Hardy NM, Atanackovic D.   +19 more
europepmc   +1 more source

Remodelling of HeLa nuclear structure and function for adenovirus 5 replication and transcription during lytic infection: an ultrastructural, autoradiographic and immunocytochemical study.

, 1993
Xia Chen
openalex   +2 more sources

Improved Adenovirus Vectors for Infection of Cardiovascular Tissues [PDF]

, 2001
Menzo Havenga, Angelique A. C. Lemckert, Jos Grimbergen, Ronald Vogels, L.G.M. Huisman, D. Valerio, A. Bout, Paul H.A. Quax   +7 more
openalex   +1 more source

Mechanotransduction Mediated by PDLIM5: The Critical Role of Serpin E2/Integrin β3‐Cytoskeleton‐Nucleoskeleton Axis in Mechanical Osteogenic Programming

Cell Proliferation, EarlyView.
Large segmental bone defects can result in non‐union of fractures and present a formidable challenge in clinical management. This study aims to investigate the role of mechanical stimulation in regulating osteogenic differentiation of stem cells via the mechanosensitive protein PDLIM5, thereby promoting bone regeneration and repair.
Yuchao Yang, Shutong Wu, Yining Wang, Jiajun Tang, Jiaxuan Liu, Jinyang Wang, Yunfeng Li, Asmat Ullah Khan, Muhammad Akram Khan, Wenqing Liu, Jinhui Zhu, Konghe Hu, Jingxing Dai, Jun Ouyang   +13 more
wiley   +1 more source

Approach for defining human adenovirus infection and disease for central review adjudication in clinical studies. [PDF]

Pediatr Transplant
Fisher BT, Blumenstock J, Boge CLK, Shuster S, Seif AE, Green M, Michaels MG, Alexander JL, Ardura MI, Miller TP, Hijano DR, Muller WJ, Schuster JE, Green AM, Dulek DE, Kajon AE, Danziger-Isakov L.   +16 more
europepmc   +1 more source

Chemotherapy of Adenovirus Infections

, 2019
openaire   +4 more sources

Tryptophan Suppresses FTH1‐Driven Ferritinophagy, a Key Correlate of Prognosis in Hepatocellular Carcinoma

Cell Proliferation, EarlyView.
Intracellular tryptophan levels modulate selective autophagy of FTH1 via the NCOA4 pathway. This autophagic process then inhibits 6‐HMT synthesis, which then results in an increase in reactive oxygen species and ferroptosis. ABSTRACT Hepatocellular carcinoma (HCC) remains a lethal malignancy with limited therapeutic options.
Xinxiang Cheng, Xin Ge, Chi Zhang, Xingye Yang, Zhengxin Yu, Min Zhang, Wen Cao, Qingtao Ni, Yang Liu, Songbing He, Yin Yuan   +10 more
wiley   +1 more source

Adenoviral fiber-knob based vaccination elicits efficient neutralizing antibodies and T cell responses against adenovirus infection. [PDF]

Virol J
Orabi A, Shameli K, Protzer U, Moeini H.
europepmc   +1 more source

CDK12 Inactivation Attenuates Prostate Cancer Progression by Inhibiting BNIP3‐Mediated Mitophagy

Cell Proliferation, EarlyView.
In response to enzalutamide, damaged mitochondria are targeted for mitophagic degradation through the binding of BNIP3 to LC3, forming autophagosomes that are subsequently transported to lysosomes for degradation. These self‐protective mechanisms promote mitochondrial renewal, reduce oxidative stress and finally contribute to cancer cell survival ...
Mengjun Huang, Hanqi Lei, Tongyu Tong, Hailin Zou, Binyuan Yan, Fei Cao, Yiting Wang, Qiliang Teng, Bin Xu, Juan Luo, Yupeng Guan, Shaohong Lai, Peng Li, Jun Pang   +13 more
wiley   +1 more source