Results 141 to 150 of about 354,753 (310)

Testing adequacy of codon substitution models

open access: yes
In phylogenetic inference, codon substitution models are mainly used to detect positive selection, which is a sign of adaptive molecular evolution at the protein level.
Tofighi, Fatemeh
core  

Data‐Driven SuStaIn Model of Disability Progression in Amyotrophic Lateral Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether ordinal Subtype and Stage Inference (SuStaIn) applied to routine ALSFRS‐R item scores can identify reproducible disability progression patterns in amyotrophic lateral sclerosis (ALS) and provide clinically meaningful staging.
Giammarco Milella   +5 more
wiley   +1 more source

Financial Risk, Capital Adequacy and Liquidity Performance of Deposit Money Banks in Nigeria [PDF]

open access: yes
The objective of this study was to examine the effect of financial risk on liquidity performance of Deposit Money Banks (DMBs) in Nigeria, with capital adequacy as a moderator. The study specifically examined the mediating role of capital adequacy on the
Gloria Ogochukwu, Okafor   +2 more
core  

Boundary‐Dependent Sleep–Wake Dysregulation in Idiopathic Hypersomnia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Idiopathic hypersomnia (IH) presents with excessive daytime sleepiness (EDS) despite apparently preserved nocturnal sleep, challenging traditional models of hypersomnolence based on sleep loss or fragmentation. We aimed to test the hypothesis that EDS in IH reflects excessive stabilization of the sleep state, consistent with ...
Samantha Mombelli   +13 more
wiley   +1 more source

Clinical Impact of MGMT Promoter Methylation in IDH‐Mutant Gliomas: Influence of Threshold Selection and Clinical Confounding

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background The clinical relevance of MGMT promoter methylation in IDH‐mutant gliomas remains controversial in the era of molecular classification. We aimed to systematically evaluate its clinical relevance by integrating quantitative assessment, cutoff exploration, and adjustment for clinical confounding.
Haihui Jiang   +7 more
wiley   +1 more source

The impact of banks’ capital adequacy regulation on the economic system: an agent-based approach [PDF]

open access: yes
Since the start of the financial crisis in 2007, the debate on the proper level leverage of financial institutions has been flourishing. The paper addresses such crucial issue within the Eurace arti?cial economy, by considering the effects that different
Silvano Cincotti   +2 more
core  

Ofatumumab Therapy and Long‐Term Seizure Outcomes of Patients With Relapsing Anti‐NMDA Receptor Encephalitis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There is a lack of studies on seizure outcomes associated with ofatumumab therapy in patients for relapsing anti‐N‐methyl‐D‐aspartate (NMDA) receptor encephalitis. We aimed to evaluate long‐term seizure outcomes of ofatumumab therapy for relapsing anti‐NMDA receptor encephalitis.
Jian Wang, Mengjiao Li, Ping Kong
wiley   +1 more source

Report of the Special Committee on Foster Care Adequacy to the 2016 Kansas Legislature.

open access: yes, 2016
"January, 2016.""The Committee makes the following conclusions and recommendations: 1)-- In considering the best interest of a child, evidence-based peer-reviewed research on family structure be considered a high priority in making foster care placement ...
Kansas Legislature. Special Committee on Foster Care Adequacy.
core   +1 more source

A critique on the proposed use of external sovereign credit ratings in Basel II [PDF]

open access: yes, 2003
This paper deals with the proposed use of sovereign credit ratings in the "Basel Accord on Capital Adequacy" (Basel II) and considers its potential effect on emerging markets financing.
Kräussl, Roman, Kraeussl, Roman
core  

Race and Household Income Are Associated With Disease Outcomes in Pediatric Patients With Antineutrophil Cytoplasmic Antibody–Associated Vasculitis Hospitalized in the United States

open access: yesArthritis Care &Research, EarlyView.
Objective Race and household income impact outcomes in patients with rheumatic conditions; however, their role in pediatric antineutrophil cytoplasmic antibody (ANCA)–associated vasculitis (AAV) remains poorly understood. We aimed to evaluate whether race and ethnicity and household income are associated with severe AAV disease and renal outcomes among
Roberto Alejandro Valdovinos   +2 more
wiley   +1 more source

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