Results 81 to 90 of about 41,061 (259)

Compartmentalisation in cAMP signalling: A phase separation perspective

British Journal of Pharmacology, EarlyView.
Cells rely on precise spatiotemporal control of signalling pathways to ensure functional specificity. The compartmentalisation of cyclic AMP (cAMP) and protein kinase A (PKA) signalling enables distinct cellular responses within a crowded cytoplasmic space.
Milda Folkmanaite, Manuela Zaccolo
wiley   +1 more source

Accelerator and zinc-free prevulcanized latex based on natural rubber-bearing benzyl chloride groups

eXPRESS Polymer Letters
The present study aimed to prepare prevulcanized latex from modified natural rubber (NR) latex, graft copolymers of natural rubber and poly(vinylbenzyl chloride), NR-g-PVBC.
Anchisa Bunsanong, Bencha Thongnuanchan, Rattanawadee Ninjan, Subhan Salaeh, Natinee Lopattananon, Abdulhakim Masa   +5 more
doaj   +1 more source

Serum Copeptin Rises After Tolvaptan for Hyponatraemia, but Does Not Predict Risk of Rapid Sodium Rise: Pre‐Specified Secondary Analysis of the TVFR Trial

Clinical Endocrinology, EarlyView.
ABSTRACT Objective Hyponatraemia is a common electrolyte disorder often driven by excess arginine vasopressin (AVP). Copeptin is a stable surrogate marker co‐secreted with AVP. It is unclear whether treatment of hyponatraemia with tolvaptan, an AVP‐V2 receptor antagonist, impacts copeptin.
Annabelle M. Warren, Kay Weng Choy, Rudolf Hoermann, Nicholas Russell, Mathis Grossmann   +4 more
wiley   +1 more source

How Common Is Hypercortisolism in Patients With Hypertension? Risk Factors, Epidemiology, and Making a Diagnosis

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Endogenous hypercortisolism (EHC) is an underrecognised and clinically significant contributor to hypertension, particularly resistant hypertension. Once viewed as a rare entity, EHC is now understood as a spectrum of cortisol excess associated with adverse cardiometabolic outcomes and target‐organ damage.
Omar Al Dhaybi, Deepak L. Bhatt
wiley   +1 more source

ADHS-ZEBRA

Zeitschrift für Kinder- und Jugendpsychiatrie und Psychotherapie
Zusammenfassung: Die Diagnostik der Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) erfordert gemäß S3-Leitlinie den Nachweis einer bereits im Kindesalter bestehenden Symptomatik. Dies stellt insbesondere bei Jugendlichen und jungen Erwachsenen eine Herausforderung dar.
Johanna Waltereit, Charlotte Borghoff, Martin Schulte-Rüther, Veit Roessner, Robert Waltereit   +4 more
openaire   +1 more source

A chemo‐enzymatic colorimetric cascade for detecting ethylene glycol contamination

The FEBS Journal, EarlyView.
A chemo‐enzymatic cascade is developed for ethylene glycol (EG) detection. EG is oxidized by GoADH with C1‐mediated cofactor recycling to produce glycolaldehyde (GAL). GAL subsequently reacts with purpald to generate a detectable purple chromophore.
Tawatchai Singphongam, Tadtarit Anujareewat, Wachirawit Chinantuya, Pratchaya Watthaisong, Chayasith Uttamapinant, Somchart Maenpuen, Ruchanok Tinikul   +6 more
wiley   +1 more source

Fatigue Crack Modeling of Railheads Using a Nonlinear Cohesive Zone Model

Fatigue &Fracture of Engineering Materials &Structures, EarlyView.
ABSTRACT Subsurface fatigue crack growth within railheads can be deleterious leading to catastrophic failures in rails. This study aims to model the fatigue crack growth originating at the subsurface level within railheads. Towards that end, a finite element modeling approach is utilized wherein complex crack growth is explicitly modeled using a ...
Santosh Reddy Kommidi, Hesam Mortazavi, Yong‐Rak Kim, David H. Allen   +3 more
wiley   +1 more source

Diferenças relacionadas com o género na libertação da hormona antidiurética (ADH) após administração de catinonas sintéticas em ratos Wistar

RevSALUS
Introdução: As catinonas sintéticas provocam efeitos psicoativos semelhantes aos das anfetaminas clássicas1. As anfetaminas, em particular a 3,4-metilenodioximetanfetamina (MDMA), podem induzir hiponatremia mediada pela serotonina através de um aumento ...
Ana Carolina Faria, Diana Dias da Silva
doaj   +1 more source

The Development and Validation of the Partial Denture Experience Questionnaire (P‐DEQ): Reliability and Validity

Gerodontology, EarlyView.
ABSTRACT Introduction This paper describes the development and preliminary validation of the Partial Denture Experience Questionnaire (P‐DEQ), a new, condition‐specific instrument designed to measure the multifaceted impacts of living with removable dentures. Methods The P‐DEQ was developed using a multi‐phase, mixed‐methods design. Item generation was
Barry J. Gibson, Nicolas Martin, Bilal El‐Dhuwaib, Gerry McKenna, Sandra Clifford, Alastair Lomax, Sarah R. Baker   +6 more
wiley   +1 more source

Assembly and engineering of BioBricks to develop an efficient NADH regeneration system

Applied and Environmental Microbiology
The cofactor regeneration system plays a crucial role in redox biocatalysis for organic synthesis and the pharmaceutical industry. The alcohol dehydrogenase (ADH)-based regeneration system offers a promising solution for the in situ regeneration of NAD(P)
Feng Cheng, Cheng-Jiao Wang, Xiao-Xiao Gong, Ke-Xiang Sun, Xi-Hang Liang, Ya-Ping Xue, Yu-Guo Zheng   +6 more
doaj   +1 more source