Results 41 to 50 of about 49,711 (269)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
Using HCI to Tackle Race and Gender Bias in ADHD Diagnosis [PDF]
arXiv, 2022 Attention Deficit Hyperactivity Disorder (ADHD) is a behavioral disorder that impacts an individual's education, relationships, career, and ability to acquire fair and just police interrogations. Yet, traditional methods used to diagnose ADHD in children and adults are known to have racial and gender bias.
arxiv
FEBS Letters, EarlyView.Metabolic dysfunction‐associated steatotic liver disease (MASLD) affects nearly one‐third of the global population and poses a significant risk of progression to cirrhosis or liver cancer. Here, we discuss the roles of hepatic dendritic cell subtypes in MASLD, highlighting their distinct contributions to disease initiation and progression, and their ...
Camilla Klaimi +3 more
wiley +1 more source
Insights into PI3K/AKT signaling in B cell development and chronic lymphocytic leukemia
FEBS Letters, EarlyView.This Review explores how the phosphoinositide 3‐kinase and protein kinase B pathway shapes B cell development and drives chronic lymphocytic leukemia, a common blood cancer. It examines how signaling levels affect disease progression, addresses treatment challenges, and introduces novel experimental strategies to improve therapies and patient outcomes.
Maike Buchner
wiley +1 more source
Characterization of fungal carbonyl sulfide hydrolase belonging to clade D β‐carbonic anhydrase
FEBS Letters, EarlyView.Here, we performed a functional analysis of the fungal enzymes belonging to clade D of the β‐class carbonic anhydrase family (β‐D‐CA). The β‐D‐CAs in the basidiomycete Gloeophyllum trabeum and the ascomycete Trichoderma harzianum showed very low activity in the hydration of CO2 but exhibited high activity in the hydrolysis of carbonyl sulfide (COS ...
Ryuka Iizuka +6 more
wiley +1 more source
Frontiers in Psychiatry, 2015 Sleep is a vital physiological behaviour in children’s development, and as such it is important to be able to efficiently and accurately assess whether children display difficulties with sleep quality and quantity.
Adria Nora Markovich +4 more
doaj +1 more source
International Journal of Evidence Based Coaching and Mentoring, 2020 Little research has examined processes involved when coaching individuals with Attention-Deficit/Hyperactivity Disorder (ADHD). A mixed methods study surveyed 117 coaches who identify themselves as ‘ADHD coaches’ to explore the frequency of use and ...
Micah Saviet, Elizabeth Ahmann
doaj +1 more source
The neurobiological basis of ADHD [PDF]
Italian Journal of Pediatrics, 2010 Attention-Deficit/Hyperactivity Disorder is not a single pathophysiological entity and appears to have a complex etiology. There are multiple genetic and environmental risk factors with small individual effect that act in concert to create a spectrum of neurobiological liability.
CURATOLO, PAOLO +2 more
openaire +5 more sources
FEBS Letters, EarlyView.The glacier ice worm Mesenchytraeus solifugus survives year‐round at 0 °C. Its ATP6 subunit, which forms a regulatory component of the proton pore in mitochondrial ATP synthase, has a carboxy‐terminal extension not found in any other organism examined to date. Here, we show that fusion of this extension to the homologous AtpB protein in E. coli results
Truman Dunkley +2 more
wiley +1 more source
Brain Sciences, 2020 The pathophysiology of attention-deficit/hyperactivity disorder (ADHD) involves deficits in performance monitoring and adaptive adjustments. Yet, the developmental trajectory and underlying neural correlates of performance monitoring deficits in youth ...
Yanni Liu +5 more
doaj +1 more source