Results 11 to 20 of about 1,023,829 (223)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Minuta 3 : Proyectos de Protocolos de Adhesión de Nicaragua

, 2012
ALADI. Comité de Representantes.
ALADI. Comité de Representantes. Grupo de Trabajo sobre Solicitud de Adhesión de la República de Nicaragua
core   +1 more source

Efectos divergentes de la inhibición de TGF-ß en metástasis óseas de cáncer de mama y pulmón

Revista de Osteoporosis y Metabolismo Mineral, 2013
Fundamento: El objetivo de este estudio radica en la determinación de la validez del factor de crecimiento transformante β (TGF-β) como diana terapéutica en modelos de metástasis óseas derivadas de distintos tipos histopatológicos del cáncer de pulmón.
Luis-Ravelo D, Antón I, Vicent S, Zandueta C, Martínez S, Valencia K, Ormazábal C, Lecanda F   +7 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Uso de papaína para mejorar la adhesión de esmalte hipomineralizado en ortodoncia, una revisión narrativa

Odontología Sanmarquina
Introducción: Una correcta adhesión forma parte fundamental de un tratamiento de ortodoncia. Existen alteraciones cualitativas del esmalte como fluorosis dental, hipomineralización incisivo molar y amelogénesis imperfecta que ofrecen un esmalte ...
Constanza Torres Lefián, Constanza Paz Lillo Fritz, Valentina Arlette Morales Ahumada, Javiera Paz Molgas Rozas, Francisca Gloria Hormazábal Sanhueza   +4 more
doaj   +1 more source

Adhesión terapéutica en neurología

Kranion, 2023
La adhesión terapéutica es una circunstancia que rodea a la práctica médica sobre la que se ha puesto énfasis en las últimas décadas, especialmente en el campo de las enfermedades crónicas. Las cifras de adhesión terapéutica suelen rondar, en general, el
Adrián Valls-Carbó
doaj   +1 more source