Results 51 to 60 of about 447,821 (312)
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Factors Influencing Reinforcement of NR and EPDM Rubbers with Short Aramid Fibers [PDF]
, 2010 Among short fiber reinforced composites, those with rubbery matrices have gained great importance due to the advantages they have in processing and low cost, coupled with high strength.
Noordermeer, J.W.M., Shirazi, M.
core +4 more sources
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
Correlating single-molecule rupture mechanics with cell population adhesion by yeast display
Biophysical Reports, 2022 Here, we present a method based on yeast surface display that allows for direct comparison between population-level cell adhesion strength and single-molecule receptor-ligand rupture mechanics. We developed a high-throughput yeast adhesion assay in which
Mariana Sá Santos +4 more
doaj +1 more source
Effects of silane coating on the properties of glass fibre and glass fibre reinforced epoxy resin [PDF]
, 2010 Single fibre tensile testing and microbond testing have been used to benchmark the influence of silane coupling agents on the performance of glass fibre for reinforced epoxy resin composites.
Reilly, S.P., Thomason, J.L.
core
High-temperature oxidation of nickel-based alloys and estimation of the adhesion strength of resulting oxide layers [PDF]
, 2011 The kinetics of isothermal oxidation (1100°C) of commercial nickel-based alloys with different content of sulfur (0.22–3.2 wt ppm) is studied. The adhesion strength in a metal/oxide system is estimated as a function of sulfur content and duration of high-
A.A. Volinsky +16 more
core +1 more source
Strength Dependence of Cadherin-Mediated Adhesions [PDF]
Biophysical Journal, 2010 Traction forces between adhesive cells play an important role in a number of collective cell processes. Intercellular contacts, in particular cadherin-based intercellular junctions, are the major means of transmitting force within tissues. We investigated the effect of cellular tension on the formation of cadherin-cadherin contacts by spreading cells ...
Ladoux, Benoit +7 more
openaire +4 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Effective adhesion strength of specifically bound vesicles
, 2005 A theoretical approach has been undertaken in order to model the thermodynamic equilibrium of a vesicle adhering to a flat substrate. The vesicle is treated in a canonical description with a fixed number of sites.
Ana-Sunčana Smith +4 more
core +1 more source
Sustainable bioplastics manufacturing from renewable sources
FEBS Open Bio, EarlyView.Bioplastics are manufactured by using polymers from different bio‐based sources. These novel materials not only offer biodegradability but also possess various functional properties that make them suitable for diverse applications. Recent developments in the preparation of bioplastics are reported, highlighting the distinct properties of each type of ...
C. Valeria L. Giosafatto +6 more
wiley +1 more source