Results 141 to 150 of about 361,269 (308)
Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero +5 more
wiley +1 more source
Influence Of Collagen Removal On Shear Bond Strength Of One-bottle Adhesive Systems In Dentin
, 2015 Purpose: The aim of this study was to evaluate the influence of collagen removal on shear bond strength (SBS) of three hydrophilic one-bottle adhesive systems in dentin.
Hara A.T. +2 more
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Investigation of the flexural properties of reinforced concrete beams strengthened by externally bonded steel plates. [PDF]
, 1980 It is sometimes necessary to strengthen in situ concrete structures. Externally bonded plate reinforcement has been successfully applied to structures with subsequent satisfactory performance.
Bloxham, John W
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FEBS Open Bio, EarlyView.Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin +3 more
wiley +1 more source
Designing for tapers and defects in FRP-strengthened metallic structures
, 2005 Adhesively bonded FRP strengthening for metallic structures relies critically on the adhesive joint between the FRP and the metal. Current best-practice in design allows the distribution of shear and peel stress along the adhesive connection to be ...
Stratford, T J; id_orcid +3 more
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RoundMi: A quantitative method to analyze mitochondrial morphology in mitotic cells
FEBS Open Bio, EarlyView.RoundMi is a workflow for rapid analysis of mitochondrial morphology in mitotic cells. By combining adaptive preprocessing with automated segmentation and quantification, it enables accurate measurements from single focal plane images, reducing acquisition time and computational demands while remaining compatible with high‐throughput fixed and live ...
Elmira Parvindokht Bararpour +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.KIF26B plays an important role in kidney development. We engineered mice lacking the C‐terminal region of KIF26B and found severe kidney defects, including bilateral renal agenesis, similar to full Kif26b knockout mice. The mutation disrupted nephron progenitor condensation and reduced Gdnf‐Wnt11 signaling, showing that the KIF26B C‐terminal region is ...
Yuta Yamamura +19 more
wiley +1 more source
Hydrostatic pressure activates HIF‐1α via β‐catenin to promote stemness in breast cancer cells
FEBS Open Bio, EarlyView.To mimic the elevated intestinal fluid pressure in breast cancers, we loaded human breast cancer cells (MCF‐7, MDA‐MB‐453, and BT‐474) to 50 mmHg hydrostatic pressure. Hydrostatic pressure exposure upregulated HIF‐1α and induced stemness in MCF‐7 and BT‐474 cells.
Da Zhai +8 more
wiley +1 more source
Amplitude Method to Detect Debonding for Stack Bond Adhesive
A numerical method was developed to detect debonding (crack initiation) condition during fatigue testing of an adhesive joint with thin steel sheets in standard configurations of coach peel and lap shear specimens.
Huang, Xiaobao
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