Results 51 to 60 of about 474,399 (285)

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Influence of adhesive thickness on local interface fracture and overall strength of metallic adhesive bonding structures

, 2013
Adhesive bonding structures are widely used in a variety of engineering fields. Their overall strength is dependent on the cohesive properties involving local interface fracture.
Wei YG(魏悦广), Xu, W (reprint author), Chinese Acad Sci, Inst Mech, State Key Lab Nonlinear Mech, Beijing 100190, Peoples R China., Xu W(许巍)   +2 more
core   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source

Study on Nanoglue Bonding Technology of State Equation Experimental Target

Yuanzineng kexue jishu, 2023
Laser loading compression is one of the main research topics in the field of inertial confinement fusion. In order to simulate and explain the experimental phenomena of materials under high strain rates and pressures generated by laser shock, the ...
CHEN Guo;ZHANG Ling;HUANG Jinglin;LIU Yansong;WANG Tao;AI Xing;LI Jun;HE Xiaoshan
doaj  

Avaliação da resistência de união à microtração de um sistema universal à dentina profunda [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências da Saúde, Programa de Pós-Graduação em Odontologia, Florianópolis, 2014.O objetivo deste estudo foi avaliar a resistência de união à microtração de um sistema adesivo ...
Gré, Cristina Parise
core  

Identifying and characterising a plant GH1 β‐glucosidase that exhibits hydrolytic activity on N‐linked glucopyranoside

FEBS Open Bio, EarlyView.
We report the first β‐glucosidase with demonstrated hydrolytic activity on an N‐linked glycopyranoside. The enzyme, native to maize, was biochemically characterised for this novel reaction, and structural modelling of the enzyme–substrate complex revealed several clues to the underlying reduced catalytic rate relative to its native O‐glycopyranoside ...
Hani Gharabli, Carlotta Chiesa, Maher Abou Hachem, Ditte Hededam Welner   +3 more
wiley   +1 more source

Effects of Novel Structure Bonding Materials on Properties of Aeronautical Acrylic

Journal of Aeronautical Materials, 2017
Novel structure bonding materials, J-351 epoxy adhesive film with low curing temperature and liquid modified acrylate SY-50s adhesive were chosen and characterized. The effects of adhesives on the mechanical properties of acrylic were studied.
LI Zhisheng, ZHANG Hongfeng, LI Lei, YAN Yue   +3 more
doaj   +1 more source

Structural studies and functional engineering of NanX: an anhydro‐sialic acid transporter from Escherichia coli

FEBS Open Bio, EarlyView.
Biophysical characterisation shows that NanX, a membrane transport protein from the major facilitator superfamily (MFS), forms both monomers and dimers after purification. AlphaFold modelling and substrate docking provide information on residues likely involved in substrate recognition for NanX and another MFS member, NanT.
Michael C. Newton‐Vesty, Kelsi R. Hall, Zachary D. Tillett, Liam S. Turk, James S. Davies, Michael J. Currie, Hamish G. Brown, Sepideh Valimehr, Peter D. Mace, Andrew E. Whitten, Santosh Panjikar, Eric Hanssen, Rachel A. North, Renwick C.J. Dobson   +13 more
wiley   +1 more source

Pembuatan lem sintetik dan aplikasinya pada alas kaki

Majalah Kulit, Karet, dan Plastik, 2008
Footwear can be categorized as one of labour intensive and very superior export commodities, consequently the product quality must be maintained and be continually improved.
Arum Yuniari, Herminiwati Herminiwati
doaj   +1 more source