Results 21 to 30 of about 120,520 (249)

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

Degradation of Mechanical Performance of Hoop Head Tenon-Mortise Joint of Tusi Manor with Decay Disease in Tibetan Areas in Yunnan

Buildings
(1) The Hoop Head Tenon-mortise Joint (HHTMJ) in the Tusi Manor in Tibetan areas in Yunnan, China, has a serious decay phenomenon. To understand the effect of decay on the seismic performance of HHTMJ, (2) the five groups of HHTMJ and small-size Pinus ...
Zhengquan Nong, Heng Liu, Kua Wu, Man Yin, Zhe Yuan, Yanwei Su, Mingli Qiang   +6 more
doaj   +1 more source

A review on the applications of nanotechnology in orthodontics [PDF]

Nanomedicine Journal, 2019
Objective (s): Nanotechnology has gained importance in recent years due to its ability in the enhancement of materials properties and other specifications such as antimicrobial properties.
Soodeh Tahmasbi, Fatemeh Mohamadian, Sehre Hosseini, Leila Eftekhar   +3 more
doaj   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Inhibition effect of bamboo leaves extract on cold rolled steel in Cl3CCOOH solution

Journal of Materials Research and Technology, 2017
The corrosion inhibition by Dendrocalamus brandisii leaves extract (DBLE)/major flavonoid of cold rolled steel (CRS) in trichloroacetic acid (Cl3CCOOH) solution was investigated by weight loss, electrochemical techniques and atomic force microscope (AFM).
Xianghong Li, Shuduan Deng, Nan Li, Xiaoguang Xie   +3 more
doaj   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Juniper Tectonic Features and Their Annual Ring Width Response to Precipitation in Lijiang, Yunnan Province, China

Applied Sciences
This study examines Lijiang Juniper from Yunnan Province. Through visual inspection, cross-section analysis, and separation tests, it analyzes the macroscopic and microscopic characteristics of Juniper wood from Baoshan Township, Lijiang City. The annual
Xiujuan Qin, Xiaolong Wu, Yuanxiang Fu, Jinyi Zheng, Lei Qin   +4 more
doaj   +1 more source

Mitochondrial fatty acid oxidation is stimulated by red light irradiation

FEBS Letters, EarlyView.
Light at different wavelengths has distinct effects on keratinocyte viability and metabolism. UVA light abrogates metabolic fluxes. Blue and green light have no effect on metabolic fluxes, while red light enhanced oxidative phosphorylation by promoting fatty acid oxidation. Keratinocytes are the primary constituents of sunlight‐exposed epidermis.
Manuel Alejandro Herrera, Camille C. Caldeira da Silva, Maiza Von Dentz, Mauricio S. Baptista, Alicia J. Kowaltowski   +4 more
wiley   +1 more source

A Study on the Architectural Form and Characteristics of Tusi Manors in the Yunnan–Tibet Region

Buildings
The Tusi manors in the Yunnan–Tibet region exemplify historical timber-framed architecture that seamlessly blends official and vernacular styles. It integrates the characteristics of ‘distinct regionality’ and ‘convergent ethnic identity’, embodies rich ...
Yanwei Su, Man Li, Mengshuai Cheng, Mingli Qiang, Xuebing Zhou   +4 more
doaj   +1 more source