Results 141 to 150 of about 516,498 (272)

Lactate Accelerates Early Angiogenesis and Bone Regeneration Through Macrophage M1 Polarisation

Cell Proliferation, EarlyView.
During the early stage of bone defect healing, lactate accumulates and contributes to increasing NOD1 expression by stabilising HIF1α that in turn triggers a calcium influx, which ultimately polarises macrophages towards the M1 phenotype and accelerates vascularisation of endothelial cells.
Lulu Liu, Danning Ma, Jia Song, Boon Chin Heng, Ying Huang, Xuehui Zhang, Mingming Xu, Yan Wei, Tai Wei, Jinqi Wei, Xuliang Deng   +10 more
wiley   +1 more source

Impact of neighborhood socioeconomic deprivation on implant complications after unicompartmental knee arthroplasty: a propensity-matched cohort study. [PDF]

Arch Orthop Trauma Surg
Gordon AM, Nian P, Baidya J, Mont MA.
europepmc   +1 more source

A bio‐ecological model for early screening of developmental coordination disorder

Developmental Medicine &Child Neurology, EarlyView.
Plain language summary: https://onlinelibrary.wiley.com/doi/10.1111/dmcn.70069 Abstract Aim To develop and externally validate a bio‐ecological model for early screening of developmental coordination disorder (DCD) using maternal and environmental risk factors from electronic health records, aimed at improving early detection in children under 5 years.
Xiaotian Dai, Tai Ren, Gareth Williams, Gary Jones, Fei Li, Wenchong Du, Jing Hua   +6 more
wiley   +1 more source

Obesity Treatments and Weight Changes in Clinical Practice After Discontinuation of Semaglutide or Tirzepatide

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Aims To describe obesity treatments in real‐world settings after discontinuation of semaglutide or tirzepatide and variability in weight change post‐discontinuation. Materials and Methods This retrospective cohort study used electronic health records from 1 January 2021, to 30 June 2025, in a large health system in Ohio and Florida.
Hamlet Gasoyan, Rebecca Schulte, Christopher B. Boyer, Nicholas J. Casacchia, W. Scott Butsch, Phuc Le, Ali Aminian, Marcio L. Griebeler, Bartolome Burguera, Michael B. Rothberg   +9 more
wiley   +1 more source

Exploring associations between area deprivation index, income, and loneliness among cancer caregivers. [PDF]

Support Care Cancer
Pitzer K, Jabbari J, Demiris G, Sedhom R, Benson JJ, Oliver DP, Washington KT.   +6 more
europepmc   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, EarlyView.
This study reveals a noncanonical role for Jagged1 in endothelial mechanotransduction. Shear stress modulates Jagged1 expression and subcellular localization. Loss of Jagged1 attenuates mechanotransduction and reduces Src, VEGFR2, and ERK signaling. Direct mechanical stimulation of Jagged1 induces activation of these signaling pathways.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Impact of Combined Interventions and Early Home Care Activation on 30-Day Hospital Readmissions: A Retrospective Observational Study. [PDF]

Medicina (Kaunas)
Azzellino G, Vagnarelli P, Aitella E, Cerratti F, Mengoli L, Ginaldi L, De Martinis M.   +6 more
europepmc   +1 more source

A person‐centered and genetically informed approach toward characterizing multidomain resilience to neighborhood disadvantage in youth

Journal of Child Psychology and Psychiatry, EarlyView.
Background Examining resilience to adversity across multiple behavioral domains (e.g., psychological well‐being, social functioning) can better characterize positive development and inform novel prevention and intervention efforts. However, few studies have employed person‐centered methods to examine individual profiles of resilience across multiple ...
Jessica L. Bezek, Elizabeth A. Shewark, Gabriela L. Suarez, Kelly L. Klump, S. Alexandra Burt, Luke W. Hyde   +5 more
wiley   +1 more source

The Impact of Socioeconomic Deprivation on Anti-Vascular Endothelial Growth Factor Therapy and Ocular Response in Patients With Diabetic Macular Edema. [PDF]

J Vitreoretin Dis
Groothoff JD, Elander AG, Wang SK, Whiteside HM, Rigdon J, Ong SS.   +5 more
europepmc   +1 more source

Neurodevelopmental conditions and adaptive functioning – a co‐twin control study

Journal of Child Psychology and Psychiatry, EarlyView.
Background Challenges in adaptive or daily functioning are inherent to diagnostic criteria for neurodevelopmental conditions (NDCs). However, less is known regarding the influence of factors that may confound the association between NDCs and adaptive functioning.
Johan Isaksson, Filippa Eklund, Karl Lundin Remnélius, Melissa H. Black, Sven Bölte   +4 more
wiley   +1 more source