Results 71 to 80 of about 170,007 (311)

Distinct Neuropsychiatric Profiles Associated With 17p11.2 Deletions and RAI1 Variants in Smith–Magenis Syndrome

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Smith–Magenis syndrome (SMS) results from either a recurrent 17p11.2 deletion or pathogenic variants in the retinoic acid induced 1 gene (RAI1). While neurodevelopmental impairment and behavioral dysregulation are well recognized, systematic genotype‐stratified analyses across psychiatric domains remain limited.
Albin Blanc, Christophe Nemos, Céline Bonnet, Mathilde Renaud, Sandra Chapuis, Pauline Boiroux, Marie‐Noëlle Babinet, Caroline Demily   +7 more
wiley   +1 more source

On the stability of ADI methods

DAIMI Report Series, 2017
When solving parabolic equations in two space dimensions implicit methods are preferred to the explicit method because of their better stability properties. Straightforward implementation of implicit methods require time-consuming solution of large systems of linear equations, and ADI methods are preferred instead.
openaire   +2 more sources

Low-rank plus sparse decomposition for exoplanet detection in direct-imaging ADI sequences. The LLSG algorithm [PDF]

, 2016
Data processing constitutes a critical component of high-contrast exoplanet imaging. Its role is almost as important as the choice of a coronagraph or a wavefront control system, and it is intertwined with the chosen observing strategy.
C. Gonzalez, O. Absil, P. Absil, Marc Van Droogenbroeck, D. Mawet, J. Surdej   +5 more
semanticscholar   +1 more source

Immune Modulatory Therapy for Severe Dengue Hemorrhagic Fever in a Patient With Mitochondrial Complex I Deficiency: A Case Report

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Dengue virus (DENV) poses a serious global health challenge, particularly in cases of dengue hemorrhagic fever (DHF). Patients with preexisting mitochondrial disorders may be at increased risk for complications due to the specific impact of DENV on mitochondrial‐dependent cellular processes and immune function.
Audra N. Iness, Ameya S. Walimbe, Emily R. Strouphauer, Michio Hirano, Alejandro D. Iglesias, Valentina Emmanuele, Caitlin C. Griffin, Sheldon L. Kaplan, William A. Gomes, Karen K. Moeller, Stephen F. Kralik, Fernando Scaglia   +11 more
wiley   +1 more source

The influence of the guided inquiry method and critical thinking on the learning outcomes of culinary arts in class X high school students

Jurnal Inovasi dan Teknologi Pembelajaran
Abstrak: Pembelajaran yang memberikan pengalaman dan partisipasi siswa adalah pembelajaran inkuiri karena pembelajaran inkuiri menuntut siswa untuk melakukan aktivitas, mengamati, menganalisis, dan menarik kesimpulan dari aktivitas yang diamati.
Wawan Gunawan, Yunus Karyanto, Yoso Wiyarno, Atiqoh Atiqoh, Suharti Suharti, Harwanto Harwanto   +5 more
doaj   +1 more source

A Phase II Study of Arginine Deiminase (ADI-PEG20) in Relapsed/Refractory or Poor-Risk Acute Myeloid Leukemia Patients

Scientific Reports, 2017
Exogenous arginine is required for growth in some argininosuccinate synthetase (ASS)-deficient cancers. Arginine deiminase (ADI) inhibits growth in various ASS-deficient cancers by depleting arginine. The efficacy of pegylated ADI (ADI-PEG20) in relapsed/
H. Tsai, S. Jiang, W. Hung, G. Borthakur, Sheng-fung Lin, N. Pemmaraju, E. Jabbour, J. Bomalaski, Ya-Ping Chen, H. Hsiao, Ming-Chung Wang, C. Kuo, Hung Chang, S. Yeh, J. Cortes, Li‐Tzong Chen, Tsai-Yun Chen   +16 more
semanticscholar   +1 more source

A Pragmatic Trial of a Shared Decision‐Making Intervention to Improve Medication Adherence and Outcomes in Systemic Lupus Erythematosus: The HCQ‐SAFE Study

Arthritis &Rheumatology, EarlyView.
Objective Hydroxychloroquine (HCQ) nonadherence in systemic lupus erythematosus (SLE) stemming from decision complexities can be improved with shared decision‐making (SDM) tools clarifying benefits and harms. This study aimed to develop and evaluate HCQ‐SAFE, a pictogram‐based SDM tool during SLE visits.
Caroline Packee, Jay J. Patel, Jessica Kent, Betty Chewning, Sancia Ferguson, Patricia Tellez‐Giron, David Gazeley, Christie M. Bartels, Shivani Garg   +8 more
wiley   +1 more source

A phase 1 study of ADI-PEG 20 and modified FOLFOX6 in patients with advanced hepatocellular carcinoma and other gastrointestinal malignancies

Cancer Chemotherapy and Pharmacology, 2018
PurposeArginine depletion interferes with pyrimidine metabolism as well as DNA damage repair pathways. Preclinical data indicates that pairing pegylated arginine deiminase (ADI-PEG 20) with fluoropyrimidines or platinum enhances cytotoxicity in vitro and
J. Harding, R. Do, I. Dika, E. Hollywood, Khrystyna Uhlitskykh, E. Valentino, P. Wan, Casey R. Hamilton, Xiaoxing Feng, A. Johnston, J. Bomalaski, Chien-Feng Li, E. O’Reilly, G. Abou-Alfa   +13 more
semanticscholar   +1 more source

The ORCA‐TWIN qCMOS Experiment I. Science Case and Commissioning at Calar Alto Observatory

Astronomische Nachrichten, EarlyView.
ABSTRACT We describe a pilot study to explore a new generation of fast and low noise CMOS image sensors for time domain astronomy, using two remote telescopes with a baseline of 1635 km. The experiment involves direct imaging with novel qCMOS image sensor technology that combines fast readout with sub‐electron readout noise.
Martin M. Roth, Paško Roje, Stella Vješnica, Stefan Cikota, Alex J. Brown, Mike Kretlow, Marco Azzaro, Santiago Reinhart, Jesús Aceituno, Harry Dawson, Carsten Denker, Torsten Enßlin, Stephan Geier, Thomas Granzer, Thomas Kupfer, Gianluca Li Causi, Samaya Nissanke, José Luis Ortiz, Fernando Pedichini, Katja Poppenhäger, Axel Schwope   +20 more
wiley   +1 more source

Distribution Patterns and Spatial Relationships in the Perspective of Tourism Destination Typology [PDF]

Local Wisdom
As one of Bali's leading tourist regions, Gianyar Regencycontinues to develop tourism destinations in support of the regional tourism development plan and vision of "Realizing High-Quality, Competitive, Sustainable, and ...
Anak Agung Sagung Alit Widyastuty, Siti Nuurlaily Rukmana, Moch. Shofwan, Anak Agung Gede kamajaya Waisnawayadnya   +3 more
doaj   +1 more source