Results 41 to 50 of about 751 (145)
Dermatologic Toxicities Associated With Novel Pan‐RAS/RAF Inhibitors
ABSTRACT Background The mitogen‐activated protein kinase (MAPK) pathway plays a key role in cell‐cycle regulation and tumor progression in cancer. Dermatologic toxicities (DTs) to newer pan‐RAS (RMC‐6236) and pan‐RAF (LXH254/naporafenib) inhibitors are emerging.
Lin J. He +11 more
wiley +1 more source
Abstract Background and aims Real‐world evaluation of clinical characteristics and treatment profile of patients with idiopathic pulmonary fibrosis (IPF) is needed to establish areas for improvement according to evidence‐based recommendations. This study evaluated the clinical characteristics and treatment profile of patients with IPF from the ...
Michelle Chee +31 more
wiley +1 more source
Outcomes of Live Virus Vaccination in Patients With Vascular Anomalies Being Treated With Sirolimus
ABSTRACT Background Live vaccination in patients with vascular anomalies (VA) receiving sirolimus remains controversial due to immunosuppressive effects and theoretical risks. Procedure This single‐center retrospective study included patients with VA less than 4 years old at the start of sirolimus therapy who were incompletely vaccinated.
Svatava Merkle +5 more
wiley +1 more source
Mortality Attributable to Hepatitis B and C in Italy, Romania, and Spain, 2022 Estimates
ABSTRACT Background and Aims Reliable data on viral hepatitis–related deaths remain limited, challenging assessment of progress towards the WHO elimination targets for mortality. To address this gap, we estimated hepatitis B‐ and C‐attributable mortality in Italy, Romania, and Spain for 2022.
Oleksandr Korotych +54 more
wiley +1 more source
ABSTRACT Purpose Malignant rhabdoid tumor of the kidney (MRTK) is a rare, aggressive tumor seen in young children. The optimal timing of resection for locally advanced tumors is not well‐defined. The purpose of this study is to evaluate modern oncologic outcomes and the impact of surgical timing. Methods A multicenter retrospective review was performed
Hannah N. Rinehardt +76 more
wiley +1 more source
ABSTRACT Objective Sturge–Weber syndrome (SWS) symptoms frequently overlap in neurological acute crises (ACs) presenting with seizures, stroke‐like episodes (SLE), and headaches. Recent efforts to develop a prospective drug trial highlighted the need for a new outcome measure capable of quantifying these symptoms during an SWS AC.
Kieran D. McKenney +3 more
wiley +1 more source
MyoRep: A Novel Reporter System to Detect Early Muscle Atrophy In Vitro and In Vivo
ABSTRACT Background Muscle atrophy occurs during physiological (i.e., fasting) and pathological conditions (i.e., cancer) and anticipates death. Since not all patients will undergo muscle wasting, it would be highly useful to identify them soon to intervene early.
Andrea D. Re Cecconi +11 more
wiley +1 more source
AEG‐AESPANC‐OPGE‐SIED‐SPG Ibero‐Latin American Guidelines on Acute Pancreatitis (iLATAM‐AP)
ABSTRACT Introduction Acute pancreatitis (AP) is a major cause of gastrointestinal hospitalizations worldwide. Although typically self‐limiting, up to one‐third of cases develop complications associated with increased morbidity and mortality. Despite recent advances that have improved outcomes, clinical heterogeneity necessitates updated, evidence ...
Karina Cárdenas‐Jaén +44 more
wiley +1 more source
Holmes-Adie syndrome and vitamin B12 - associated peripheral neuropathy: An association or coincidence? [PDF]
Parihar AS, Mani A, Mishra AB.
europepmc +1 more source
Long‐term follow‐up (almost 7 years) of an ET/ET‐plus cohort (n = 22) shows heterogeneous and partly non‐linear progression, with a contribution of aging to disease burden. Tremor spreads anatomically over time, with selective worsening of kinetic tremor and increasing burden of soft neurological signs.
Luca Angelini +10 more
wiley +1 more source

