Results 211 to 220 of about 190,728 (311)

Single‐Cell Transcriptomic Analysis of Tumor Heterogeneity and the Microenvironment in Pseudomyxoma Peritonei

Advanced Science, EarlyView.
This study presents a single‐cell atlas of pseudomyxoma peritonei spanning primary and paired metastatic lesions. Distinct epithelial substates, stromal remodeling, immune exclusion, lipid metabolic reprogramming, and a candidate angiogenic network were identified in metastatic lesions.
Xi Li, Lei Wang, Lei Ai, Zimeng Li, Zhaochangci Chen, Yuchen Luo, Tianran Zhang, Mengjia Liao, Songhao Wang, Jiajia Cui, Ke Liu, Chengxian Guo, Guodong Liu, Jiye Yin, Wei Wu   +14 more
wiley   +1 more source

A Comprehensive Evaluation of Adiposity Indices on 20-Year Cumulative Incidence of Type 2 Diabetes: The ATTICA Cohort Study (2002-2022). [PDF]

Clin Obes
Kechagia I, Giannakopoulou SP, Barkas F, Yannakoulia M, Liberopoulos E, Sfikakis PP, Pitsavos C, Panagiotakos D.   +7 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Short Sleep Duration Is Positively Associated With Traditional and Non-Traditional Markers of Adiposity and Cardiometabolic Risk in Individuals at Secondary Healthcare: A Cross-Sectional Study. [PDF]

FASEB J
E Oliveira NMC, Filgueiras MS, Zanirate GA, Cândido FG, Ribeiro SAV, Hermsdorff HHM.   +5 more
europepmc   +1 more source

Mitochondrial SLC25A46 Rewires Fatty Acid Oxidation to Promote Cell Proliferation and Ferroptosis Evasion in Ovarian Cancer by Stabilizing CACT

Advanced Science, EarlyView.
Mitochondrial SLC25A46 is upregulated in ovarian cancer (OC) and correlates with poor prognosis. SLC25A46 stabilizes CACT to activate fatty acid oxidation, increasing ATP and NADPH production to drive cell proliferation and ferroptosis evasion. SLC25A46 silencing sensitizes OC cells to ferroptosis and carboplatin, offering a promising therapeutic ...
Yunge Gao, Jiatao Hao, Xiaohong Zhang, Meiting Long, Yujing Feng, Xiaoyue Liu, Xuejian Li, Shujuan Liu, Xin Guo, Xiaohui Lv   +9 more
wiley   +1 more source

Dietary Behaviours Mediate Intervention Effects on Body Composition Outcomes in Children: Evidence from a Cluster-Randomised Controlled Trial. [PDF]

Nutrients
Zhang L, Wang L, Yin CJ, Duan YQ, Ma J, Yan SY, Chin YS, Li Y, Wang HJ.   +8 more
europepmc   +1 more source

The Mind From Within: Visceral Roots of Human Cognition

Advanced Science, EarlyView.
The physiological activity of visceral organs, such as the heart, the lungs, and the gut, is surprisingly linked to many sophisticated mental operations, such as remembering the past, being aware of ourselves, making choices, and forging social bonds.
Alessandro Monti, Salvatore Maria Aglioti   +1 more
wiley   +1 more source

Body composition-defined sarcopenia phenotypes, diabetes complications, and CGM-derived glycemic profiles in frail older adults with diabetes: a cross-sectional study. [PDF]

J Nutr Health Aging
Guevara E, Simó-Servat A, Perea V, Quirós C, Puig-Jové C, Formiga F, Barahona MJ.   +6 more
europepmc   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Visceral Adiposity and Renal Health: From Pathophysiological Mechanisms to Novel Therapeutic Strategies. [PDF]

J Clin Med
Marques Vidas M, Quiroga B, Portoles J, Ortiz A, Fernández-Fernández B, Sánchez Horrillo A, Soler MJ, García-Carro C, Morales E, Bajo MA.   +9 more
europepmc   +1 more source