Results 71 to 80 of about 42,671 (271)

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Visceral Adiposity Index as a Tool for Cardiometabolic Risk in Obese Older Women [PDF]

Geriatrics, Gerontology and Aging
OBJECTIVE: To correlate anthropometric measurements, lipid profile, cardiorespiratory fitness, and visceral adiposity index (VAI) in sedentary obese older women. METHODS: Twenty-seven insufficiently active and overweight older women were included in this
Ayanne Rodrigues Cambiriba, Daniel Vicentini de Oliveira, Pablo Valdes-Badilla, Marcelo Picinin Bernuci, Sônia Maria Marques Gomes Bertoloni, Bráulio Henrique Magnani Branco   +5 more
doaj   +1 more source

Multiple non-invasive peripheral vascular function parameters with obesity and cardiometabolic risk indicators in school-aged children

BMC Pediatrics, 2022
Background The Peripheral Arterial Tonometry (PAT) technique measured by Endo-PAT™, is recently introduced for peripheral vascular assessment in youth, primarily benefits from its easy and non-invasive operation.
Wennan He, Yi Zhang, Xuesong Li, Kai Mu, Yalan Dou, Ying Ye, Fang Liu, Weili Yan   +7 more
doaj   +1 more source

Pre-pregnancy predictors of hypertension in pregnancy among Aboriginal and Torres Strait Islander women in north Queensland, Australia; a prospective cohort study [PDF]

, 2013
BACKGROUND Compared to other Australian women, Indigenous women are frequently at greater risk for hypertensive disorders of pregnancy. We examined pre-pregnancy factors that may predict hypertension in pregnancy in a cohort of Aboriginal and Torres ...
Adrian Esterman, B Jim, B McCulloch, B Sibai, C De Costa, C Hatzis, C Rudra, CL Roberts, D Jacobs, D Leonard, D Trewin, G Miller, G Zavorsky, H Abenhaim, I Mertens, J Neter, J Roberts, J Roberts, J Roberts, John Lynch, K Duckitt, K Joseph, K O’Dea, K Panaretto, KL Coyne, L Callaway, M Lindheimer, M Samuels-Kalow, R McDermott, Robyn McDermott, S Campbell, Sandra K Campbell, V Flenady, V Rodie, W Gilbert, W Hoy, World Health Organisation   +36 more
core   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Association between infancy BMI peak and body composition and blood pressure at age 5-6 years.

PLoS ONE, 2013
IntroductionThe development of overweight is often measured with the body mass index (BMI). During childhood the BMI curve has two characteristic points: the adiposity rebound at 6 years and the BMI peak at 9 months of age.
Michel H P Hof, Tanja G M Vrijkotte, Marieke L A de Hoog, Manon van Eijsden, Aeilko H Zwinderman   +4 more
doaj   +1 more source

Differential regulation of ZFAS1 splice variants by endoplasmic reticulum stress in hepatocyte cell lines

FEBS Open Bio, EarlyView.
ZFAS1 is a lncRNA promoting cell proliferation and migration, exhibiting high expression in various cancers. It is conserved, widely expressed, and produces multiple splice variants with unclear roles. We identified several splice variants in hepatocyte models, and found that inhibiting or suppressing regulators of the unfolded protein response (PERK ...
Sébastien Soubeyrand, Paulina Lau, Ruth McPherson   +2 more
wiley   +1 more source

Consumption of a high-fat meal containing cheese compared with a vegan alternative lowers postprandial C-reactive protein in overweight and obese individuals with metabolic abnormalities: a randomised controlled cross-over study. [PDF]

, 2016
Dietary recommendations suggest decreased consumption of SFA to minimise CVD risk; however, not all foods rich in SFA are equivalent. To evaluate the effects of SFA in a dairy food matrix, as Cheddar cheese, v.
Demmer, Elieke, German, J Bruce, Gertz, Erik R, Rivera, Nancy, Rogers, Tara S, Smilowitz, Jennifer T, Van Loan, Marta D, Zivkovic, Angela M   +7 more
core   +1 more source

Erythropoietin modulates hepatic inflammation, glucose homeostasis, and soluble epoxide hydrolase and epoxides in high‐fat diet‐induced obese mice

FEBS Open Bio, EarlyView.
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda, Satoru Sugimoto, Chiharu Cho, Madoka Konishi, Nozomi Inoue, Satoshi Miyagaki, Yasuhiro Kawabe, Takuro Okamura, Masahide Hamaguchi, Hisakazu Nakajima, Michiaki Fukui, Masakazu Shinohara, Tomoko Iehara   +12 more
wiley   +1 more source

Perinatal environmental and biological factors associated with adiposity peak and rebound

, 2022
L’évolution de l’adiposité de l’enfant, généralement observée grâce à la courbe d’indice de masse corporelle (IMC), est marquée par deux périodes principales : le pic et le rebond d'adiposité. L’IMC au pic et l’âge au rebond d’adiposité ont été reconnus comme facteurs prédictifs importants du risque de surpoids ou d'obésité plus tard dans l’enfance et ...
openaire   +1 more source