Results 41 to 50 of about 2,137,172 (311)

Improve Query Performance On Hierarchical Data. Adjacency List Model Vs. Nested Set Model

, 2016
Hierarchical data are found in a variety of database applications, including content management categories, forums, business organization charts, and product categories.
Cornelia Gyorodi, Romulus-Radu Moldovan-Duse, R. Gyorodi, G. Pecherle   +3 more
semanticscholar   +1 more source

ЗБЕРІГАННЯ ІЄРАРХІЧИХ СТРУКТУР В РЕЛЯЦІЙНИХ БАЗАХ ДАНИХ

Кібербезпека: освіта, наука, техніка, 2022
Системи управління реляційними базами даних і сама мова SQL не мають жодних вбудованих механізмів для зберігання та управління ієрархічними структурами. Існує кілька  різних способів представлення дерев в реляційних базах даних. В роботі розглянуто метод
Volodymyr Markitan, Mykola Vozniak, Lesia Bulatetska, Vitalii Bulatetskyi   +3 more
doaj   +1 more source

A+ Indexes: Tunable and Space-Efficient Adjacency Lists in Graph Database Management Systems

IEEE International Conference on Data Engineering, 2020
Graph database management systems (GDBMSs) are highly optimized to perform fast traversals, i.e., joins of vertices with their neighbours, by indexing the neighbourhoods of vertices in adjacency lists.
Amine Mhedhbi, Pranjal Gupta, Shahid Khaliq, S. Salihoglu   +3 more
semanticscholar   +1 more source

Research on incremental deployment mechanism of network modality for polymorphic network environment

Dianxin kexue, 2023
Polymorphic networks support diverse network requirements and can coexist, evolve, and change on a unified physical or logical infrastructure in the form of network modality.They can maximize the innovation vitality of network technology driven by new ...
Jiong LI, Yuxiang HU, Pengshuai CUI, Le TIAN, Yongji DONG   +4 more
doaj   +2 more sources

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Social Network Graph Generation Method Satisfying Personalized Differential Privacy

Taiyuan Ligong Daxue xuebao
Purposes Aiming at the problem that the randomized neighbor list method of directly disturbing the neighbor list in the existing local differential privacy social network graph generation algorithm will lead to excessive noise and imbalanced privacy ...
Rui GAO, Xuebin CHEN, Zheng GU, Yuanhuai ZOU   +3 more
doaj   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source