Results 51 to 60 of about 71,751 (310)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Social Network Graph Generation Method Satisfying Personalized Differential Privacy

Taiyuan Ligong Daxue xuebao
Purposes Aiming at the problem that the randomized neighbor list method of directly disturbing the neighbor list in the existing local differential privacy social network graph generation algorithm will lead to excessive noise and imbalanced privacy ...
Rui GAO, Xuebin CHEN, Zheng GU, Yuanhuai ZOU   +3 more
doaj   +1 more source

Simple DFS on the Complement of a Graph and on Partially Complemented Digraphs [PDF]

, 2013
A complementation operation on a vertex of a digraph changes all outgoing arcs into non-arcs, and outgoing non-arcs into arcs. A partially complemented digraph $\widetilde{G}$ is a digraph obtained from a sequence of vertex complement operations on $G ...
Joeris, Benson, Lindzey, Nathan, McConnell, Ross M., Osheim, Nissa   +3 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

On dynamic breadth-first search in external-memory [PDF]

, 2010
We provide the first non-trivial result on dynamic breadth-first search (BFS) in external-memory: For general sparse undirected graphs of initially $n$ nodes and O(n) edges and monotone update sequences of either $\Theta(n)$ edge insertions or $\Theta(n)$
Meyer, Ulrich
core   +1 more source

Adjacency Matrix Based Energy Efficient Scheduling using S-MAC Protocol in Wireless Sensor Networks

, 2012
Communication is the main motive in any Networks whether it is Wireless Sensor Network, Ad-Hoc networks, Mobile Networks, Wired Networks, Local Area Network, Metropolitan Area Network, Wireless Area Network etc, hence it must be energy efficient.
Bhatt, Ravindara, Singh, Shweta
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

(Semi-)External Algorithms for Graph Partitioning and Clustering

, 2014
In this paper, we develop semi-external and external memory algorithms for graph partitioning and clustering problems. Graph partitioning and clustering are key tools for processing and analyzing large complex networks.
Akhremtsev, Yaroslav, Sanders, Peter, Schulz, Christian   +2 more
core   +1 more source