Results 51 to 60 of about 2,137,172 (311)
Molecular Oncology, EarlyView.Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard +5 more
wiley +1 more source
Molecular Oncology, EarlyView.CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir +12 more
wiley +1 more source
Scientific Reports, 2017 Transcription factors (TFs) binding to specific DNA sequences or motifs, are elementary to the regulation of transcription. The gene is regulated by a combination of TFs in close proximity.
Gaofeng Pan, Jijun Tang, Fei Guo
semanticscholar +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
USENIX Conference on File and Storage Technologies, 2020 There is a growing need to perform a diverse set of real-time analytics (batch and stream analytics) on evolving graphs to deliver the values of big data to users.
P. Kumar +2 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.Generation of two normal and tumour (cancerous) paired human cell lines using an established tissue culture technique and their characterisation is described. Cell lines were characterised at cellular, protein, chromosome and gene expression levels and for HPV status.
Simon Broad +12 more
wiley +1 more source
R3MR: Region Growing Based 3D Mesh Reconstruction for Big Data Platform
IEEE Access, 2020 Visualization is one of the most intuitive and perceptible ways for information representation in the big data era. As an essential part of the visualization, 3D mesh reconstruction is facing great challenges due to its characteristics of quantity, non ...
Hong-An Li +5 more
doaj +1 more source
Strength through diversity: how cancers thrive when clones cooperate
Molecular Oncology, EarlyView.Intratumor heterogeneity can offer direct benefits to the tumor through cooperation between different clones. In this review, Kuiken et al. discuss existing evidence for clonal cooperativity to identify overarching principles, and highlight how novel technological developments could address remaining open questions.
Marije C. Kuiken +3 more
wiley +1 more source
Space-Efficient Fully Dynamic DFS in Undirected Graphs †
Algorithms, 2019 Depth-first search (DFS) is a well-known graph traversal algorithm and can be performed in O ( n + m ) time for a graph with n vertices and m edges.
Kengo Nakamura, Kunihiko Sadakane
doaj +1 more source
Dynamic asymmetric assignment problem in open multi-agent systems
Доклады Белорусского государственного университета информатики и радиоэлектроники, 2020 The purpose of the work is to develop models and algorithms for optimizing matching in dynamically generated graphs of asymmetric relations in coordinated open systems of interacting agents with centralized and collective control.
M. P. Revotjuk +3 more
doaj +1 more source