Results 61 to 70 of about 2,137,172 (311)
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source
New blocked all-pairs shortest paths algorithms operating on blocks of unequal sizes
Системный анализ и прикладная информатикаIn real-world networks, many problems imply finding the All-Pairs Shortest Paths (APSP) and their distances in a graph. Solving the large-scale APSP problem on modern multi-processor (multi-core) systems is the key for various application domains.
A. A. Prihozhy, O. N. Karasik
doaj +1 more source
Molecular determinants of signal transduction in tropomyosin receptor kinases
FEBS Open Bio, EarlyView.Tropomyosin receptor kinases control critical neuronal functions, but how do the same receptors produce diverse cellular responses? This review explores the structural mechanisms behind Trk signaling diversity, focusing on allosteric modulation and ligand bias.
Giray Enkavi
wiley +1 more source
Entropy, 2016 Complex network methodology is very useful for complex system exploration. However, the relationships among variables in complex systems are usually not clear.
Yanzhu Hu, Huiyang Zhao, Xinbo Ai
doaj +1 more source
FEBS Open Bio, EarlyView.CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Chemoresistance in bladder cancer: Macrophage recruitment associated with CXCL1, CXCL5 and CXCL8 expression is characteristic of Gemcitabine/Cisplatin (Gem/Cis) Non‐Responder tumors (right side) while Responder tumors did not show substantial tumor‐stromal crosstalk (left side). All biological icons are attributed to Bioicons: carcinoma, cancerous‐cell‐
Sophie Leypold +11 more
wiley +1 more source
A node degree dependent random perturbation method for prediction of missing links in the network [PDF]
Network Biology, 2016 In present study, I proposed a node degree dependent random perturbation algorithm for prediction of missing links in the network. In the algorithm, I assume that a node with more existing links harbors more missing links. There are two rules.
WenJun Zhang
doaj
Power-PCSR:An Efficient Dynamic Graph Storage Structure for Power-law Graphs [PDF]
Jisuanji kexueGraph data is widespread in real life and changes over time.The traditional efficient static graph storage structure,compressed sparse row/column(CSR/CSC) requires a large amount of data migration when inserting/deleting edges to/from graphs,which is not
MAO Zhixiong, LIU Zhinan, GAO Xuning, WANG Mengxiang, GONG Shufeng, ZHANG Yanfeng
doaj +1 more source
Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control
FEBS Open Bio, EarlyView.Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada +5 more
wiley +1 more source