Results 81 to 90 of about 174,987 (258)
Wind load interaction on an adjacent building
, 1978 In recent years, wind loading on buildings has been an area of active investigation by many authors. A review of this literature indicates that little information is available on the effect of an adjacent building on the pressure distribution mean force and moment coefficients and the probability density function of the peak pressures acting on a ...
Peterka, J. A., author +2 more
openaire +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Reinforcement Effects of Isolation Piles on the Adjacent Existing Tunnel in Building Construction
Advances in Materials Science and Engineering, 2019 Similar material model test and numerical simulation method were used to study the reinforcement effect of isolation piles on the existing shield tunnel structure in the adjacent building construction for analyzing foundation pit excavation and new ...
Aijun Yao +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Experimental evaluation of a vibro-impact model for two adjacent shear-building structures
MATEC Web of Conferences, 2018 The vibro-impact phenomenon is found in many engineering applications, from impact of floating ice with ships to rubbing between the stator structure and rotor blades in turbomachinery, and in most cases it is important to know the implication of this ...
Varanis Marcus +5 more
doaj +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Construction of high-rise building with underground parking in Moscow
E3S Web of Conferences, 2018 Paper presents results of scientific support to construction of unique residential building 108 m high with one storey underground part under high-rise section and 3-storey underground parking connected by underground passage.
Ilyichev Vyacheslav +2 more
doaj +1 more source