Results 81 to 90 of about 17,846 (264)

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source

Effect of stiffness of building adjacent to excavation on deformation of the excavation wall [PDF]

Numerical Methods in Civil Engineering
In contemporary urban environments, the scarcity of space and the prevalence of apartment living necessitate extensive excavation to secure adequate space and appropriate infrastructure for most construction projects.
Javad Raisianzadeh, Hesam Dehghan Khalili, Mehdi Rahmani Nejad   +2 more
doaj   +1 more source

Wind load interaction on an adjacent building

, 1978
In recent years, wind loading on buildings has been an area of active investigation by many authors. A review of this literature indicates that little information is available on the effect of an adjacent building on the pressure distribution mean force and moment coefficients and the probability density function of the peak pressures acting on a ...
Peterka, J. A., author, Zambrano, Thomas Guy, author, Fluid Mechanics and Wind Engineering Program, Fluid Dynamics and Diffusion Laboratory, Department of Civil Engineering, Colorado State University, publisher   +2 more
openaire   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

ShakeTableTestsofHigh-riseBuildingGroup-soilInteraction

工程科学与技术, 2015
:To reveal the mechanism of dynamic cross effect and the structural behavior change caused by adjacent buildings,two comparative models of soil-structure system were designed.Under the same site soil conditions,one model included a single upper structure,
熊峰, 赵丽, 谢伦武, 葛琪
doaj  

Impact of TMDI on pounding mitigation of insufficiently separated buildings exposed to earthquakes with varying frequencies

Journal of Low Frequency Noise, Vibration and Active Control
Sever damages or even total collapses were recorded due to collisions between insufficiently separated neighboring structures exposed to seismic forces.
Ayman Abd-Elhamed, Sayed Mahmoud, Alaa Sherif, Haytham Essam Amin   +3 more
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Seismic Pounding between Adjacent Building Structures

Electronic Journal of Structural Engineering, 2006
Investigations of past and recent earthquake damage have illustrated that the building structures are vulnerable to severe damage and/or collapse during moderate to strong ground motion. Among the possible structural damages, seismic induced pounding has been commonly observed in several earthquakes. A parametric study on buildings pounding response as
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source