Results 91 to 100 of about 3,278,985 (302)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Electro-Optic Segment-Segment Sensors for Radio and Optical Telescopes [PDF]

, 2012
A document discusses an electro-optic sensor that consists of a collimator, attached to one segment, and a quad diode, attached to an adjacent segment.
Abramovici, Alex
core  

Biomechanical effects of hybrid stabilization on the risk of proximal adjacent-segment degeneration following lumbar spinal fusion using an interspinous device or a pedicle screw–based dynamic fixator

, 2017
OBJECTIVEPedicle screw-rod–based hybrid stabilization (PH) and interspinous device–based hybrid stabilization (IH) have been proposed to prevent adjacent-segment degeneration (ASD) and their effectiveness has been reported.
Chi Heon Kim, Chang-Hyun Lee, Young Eun Kim, Hak Joong Lee, Dong Gyu Kim   +4 more
core   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

The Relationship Between Postoperative Variation of Adjacent Segment Three‐Dimensional Kinematics and Postoperative PI‐LL in Patients With Degenerative Lumbar Scoliosis After Short Segment Fixation

Orthopaedic Surgery
Objective The etiology of adjacent segment diseases and proximal junctional kyphosis has been related to biomechanical alterations after spinal operation.
Fei Xu, Shuai Jiang, Zhuoran Sun, Nanfang Xu, Zheyu Fan, Siyu Zhou, Yudong Zhao, Zhuofu Li, Weishi Li   +8 more
doaj   +1 more source

The incidence of adjacent segment degeneration after cervical disc arthroplasty (CDA): a meta analysis of randomized controlled trials.

, 2012
BackgroundCervical disc arthroplasty is being used as an alternative degenerative disc disease treatment with fusion of the cervical spine in order to preserve motion.
Siyue Xu, Haopeng Li (162682), Yang Baohui, Siyue Xu (162696), Baohui Yang (162678), He Xijing, Xijing He (162686), Zhang Ting, Xu Siyue, Haopeng Li, Xijing He, Baohui Yang, Ting Zhang, Ting Zhang (102583), Li Haopeng   +14 more
core   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The clinical efficacy of hybrid surgery based on the Waveflex semi-rigid dynamic internal fixation system for the treatment of lumbar degenerative diseases: over three-year follow-up study

BMC Musculoskeletal Disorders
Objective To investigate the efficacy and safety of hybrid surgery based on the Waveflex internal fixation system for the treatment of lumbar degenerative disease.
Zhiwu Zhang, Jiashen Shao, Nan Su, Xiang Li, Qi Fei, Yong Yang, Hai Meng   +6 more
doaj   +1 more source

Rigid fixation of the lumbar spine alters the motion and mechanical stability at the adjacent segment level

, 2014
Objectives: This study aims to examine the motion and stability of the adjacent segment following rigid fixation of the lumbar ...
KARAKAŞLI, AHMET, HAPA, ONUR, Taylan, Orcun, ERDURAN, MEHMET, ÇEÇEN, BERİVAN, HAVITÇIOĞLU, HASAN   +5 more
core   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source