Results 41 to 50 of about 3,278,985 (302)

Effect of lordosis on adjacent levels after lumbar interbody fusion, before and after removal of the spinal fixator: a finite element analysis

BMC Musculoskeletal Disorders, 2019
Background Literature indicates that adjacent-segment diseases after posterior lumbar interbody fusion with pedicle screw fixation accelerate degenerative changes at unfused adjacent segments due to the increased motion and intervertebral stress ...
Fon-Yih Tsuang, Jui-Chang Tsai, Dar-Ming Lai   +2 more
doaj   +1 more source

Assessment of vertebral bone mineral density and stand-alone oblique lumbar interbody fusion for adjacent segment disease and primary lumbar degenerative diseases

Journal of Orthopaedic Surgery, 2022
Purpose To evaluate the vertebral bone mineral density and the value of stand-alone oblique lumbar interbody fusion (SA OLIF) for the management of single-level adjacent segment disease (ASD) and primary lumbar degenerative diseases. Patients and methods
Jing Zhou, Chao Yuan, Chao Liu, Minghan Liu, Lei Zhou, Jian Wang   +5 more
doaj   +1 more source

Estimation of Cervical Spinal Loading and Internal Motion at Adjacent Segments after C5–C6 Fusion Using a Musculoskeletal Multi-Body Dynamics Model during the Head Flexion–Extension Movement

Applied Sciences, 2023
Cervical spinal fusion is the standard of care for treating intractable spinal diseases. However, frequent adjacent segment disease (ASD) has recently drawn a great deal of attention among clinicians and researchers.
Hao Diao, Hua Xin, Zhongmin Jin
doaj   +1 more source

Adjacent-segment effects of lumbar cortical screw–rod fixation versus pedicle screw–rod fixation with and without interbody support

, 2021
OBJECTIVE: Cortical screw-rod (CSR) fixation has emerged as an alternative to the traditional pedicle screw-rod (PSR) fixation for posterior lumbar fixation.
Bernardo de Andrada Pereira, Lehrman, Jennifer N, Turner, Jay D, Juan S. Uribe, Luke K. O’Neill, Anna G. U. Sawa, Brian P. Kelly, Piyanat Wangsawatwong, Uribe, Juan S, Sawa, Anna G, de Andrada Pereira, Bernardo, Kelly, Brian P, O\u27Neill, Luke K, Wangsawatwong, Piyanat, Jay D. Turner, Jennifer N. Lehrman   +15 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Effect of vertebral rotation on adjacent segment degeneration after the early stage of lumbar fusion surgery

BMC Surgery
Objective Related studies have shown that the torsional vertebral after fused significantly increase adjacent disc stress and accelerate degeneration. This suggests that vertebral rotation (VR) may accelerate adjacent segment degeneration (ASD).
Bin Ye, Yachao Ma, Zhipeng Tu, Peipei Huang, Zhou Yao, Zhe Wang, Zhuojing Luo, Xueyu Hu   +7 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Risk factors for adjacent segment disease after lumbar fusion [PDF]

European Spine Journal, 2009
The incidence of adjacent segment problems after lumbar fusion has been found to vary, and risk factors for these problems have not been precisely verified, especially based on structural changes determined by magnetic resonance imaging. The purpose of this retrospective clinical study was to describe the incidence and clinical features of adjacent ...
Choon Sung, Lee, Chang Ju, Hwang, Sung-Woo, Lee, Young-Joon, Ahn, Yung-Tae, Kim, Dong-Ho, Lee, Mi Young, Lee   +6 more
openaire   +2 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Lumbar Stabilization with DSS-HPS® System: Radiological Outcomes and Correlation with Adjacent Segment Degeneration [PDF]

, 2021
Arthrodesis has always been considered the main treatment of degenerative lumbar disease. Adjacent segment degeneration is one of the major topics related to fusion surgery.
Nena, Ugo, Alberto Procura, Pietro Ruggieri, Riccardo Baracco, Andrea Angelini, Procura, Alberto, Ruggieri, Pietro, Ugo Nena, Baracco, Riccardo, Angelini, Andrea   +9 more
core   +1 more source