Results 91 to 100 of about 249,494 (321)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Historical development of adjective accentuation in Croatian (suffixless, *-ьnъ and *-ъkъ adjectives)

open access: yesBaltistica, 2011
The article deals with the historical development of the accentuation of suffixless (root), *-ьnъ and *-ъkъ adjectives. Their development is analyzed in detail from their Proto-Slavic origin to their modern reflexes in Štokavian, Čakavian and Kajkavian ...
Mate Kapović
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Bare adjectives as syncretic forms

open access: yesBorealis: An International Journal of Hispanic Linguistics, 2014
The goal of this paper is to discuss the categorical status and semantic properties of the so-called adjective adverbs (ngrale 2009: 2295-2301). As these forms are actually real adjectives lacking productive gender and number agreement, we will call them
Avel·lina Suñer, Angela Di Tullio
doaj   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Художественная трансформация и актуализация имён прилагательных в тексте (на материале романа В. Набокова Лолита)

open access: yesPolilog: Studia Neofilologiczne, 2011
Artistic transformation and actualization of adjectives in the text (based on V. Nabokov’s novel Lolita) The paper reveals the artistic and figurative potential of adjectives as units of lexical and grammatical language system units in the text of V ...
Tatiana Wołyniec
doaj  

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Evaluative Grammar and Non-Standard Comparatives: A Cross-Linguistic Analysis of Ukrainian and English

open access: yesLanguages
This study examines non-standard comparative and superlative adjective forms in Ukrainian and English, emphasizing their evaluative meanings and grammatical deviations.
Oksana Kovtun
doaj   +1 more source

"Vzhledově neodolatelný", ale "povahově nesnesitelný", czyli o niektórych czeskich przymiotnikach i przysłówkach

open access: yesStudia z Filologii Polskiej i Słowiańskiej, 2015
Visually irresistible, but essentially unbearable, or on some of Czech adjectives and adverbs The present contribution from the field of comparative Slavonic word for­ mation deals with a specific feature of the Czech language, namely its frequent (in ...
Irena Bogocz
doaj   +1 more source

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