Results 121 to 130 of about 233,970 (354)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

open access: yesMolecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp   +13 more
wiley   +1 more source

What\u27s In a Name? [PDF]

open access: yes, 1970
A few years ago, when I was writing a regular column for Pageant magazine, I discovered that letters came in from many places (even far-off India and Australia) after I pointed out the obvious fact that Logan created the loganberry, Machiavelli was ...
Ashley, Leonard R. N.
core   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The role of noun imagery in the speed of processing the grammaticality of adjective-noun phrases [PDF]

open access: bronze, 1977
David A. Grant   +6 more
openalex   +1 more source

Semantic constraints on case assignment in secondary adjectival predicates in russian [PDF]

open access: yes, 2013
Adjectival secondary predicates can enter into two Case frames in Russian, the agreeing form and the Instrumental. The paper argues that these Case frames go together with two syntactic positions in the clause which are correlated with two different ...
Hinterholzl, Roland
core  

The Adjectives of Yueqing

open access: yes, 2018
This thesis explores the question of whether Yueqing, a Southern Chinese variety, has a category of adjectives. It explores the morpho-syntactic properties of nouns, verbs and adjectives, and proposes that adjectival concepts are expressed by words that belong to the syntactic category of verbs in the language.
openaire   +3 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

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