Results 101 to 110 of about 658,149 (311)

Rofecoxib and cardiovascular adverse events in adjuvant treatment of colorectal cancer [PDF]

, 2007
Background Selective cyclooxygenase inhibitors may retard the progression of cancer, but they have enhanced thrombotic potential. We report on cardiovascular adverse events in patients receiving rofecoxib to reduce rates of recurrence of colorectal ...
Christopher C. McConkey, Justine L. Smith, McConkey, Christopher C., Midgley, RS, Kerr, DJ, Janet A. Dunn, Stokes, JC, Midgley, Rachel, Claire Iveson, McConkey, CC, HASH(0x55a67f94f158), Midgley, Rachel S. J., HASH(0x55a67f45c688), Iveson, Claire, David J. Kerr, Ravi Duvvuri, Iveson, C, Patrick Julier, Julier, P, Smith, JL, Joanne C. Stokes, Langman, Michael J., Julier, Patrick, Duvvuri, Ravi, Rachel S.J. Midgley, Smith, Justine L., Michael J. Langman, Dunn, Janet A., Duvvuri, R, Kerr, David J., Kerr, David, Langman, MJ, Stokes, Joanne C., Andrew Stanley, Stanley, A, Dunn, JA, Stanley, Andrew   +36 more
core   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

CD40 antibody as an adjuvant induces enhanced T cell responses

, 2004
Monoclonal antibodies against CD40, conjugated to antigen, act as potent immunological adjuvants for primary antibody responses. We show here that CD40mAbs can also act as strong adjuvants for memory antibody responses, and for T cell responses as ...
Heath, A.W., Carlring, J., Barr, T.A., McCormick, A.L.   +3 more
core   +2 more sources

Survival Impact of Adjuvant Chemoradiotherapy in Resected Pancreatic Cancer [PDF]

Aim: Pancreatic cancer (PC) is one of the most aggressive cancers, with a 5-year survival rate of less than 50% in resectable stages. The aim of this study was to determine the survival effect of adjuvant chemoradiotherapy (CRT) in resected PC ...
Yakup İRİAĞAÇ, Abdullah SAKİN, Eyyüp ÇAVDAR, Yüksel BEYAZ, Okan AVCI, Kubilay KARABOYUN   +5 more
core   +1 more source

Exploring the influence of lactoferrin on wound healing and related signaling pathways: a systematic review

FEBS Open Bio, EarlyView.
Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo, Kátia Cristiane Hall, Matheus dos Santos Fernandez, Geovanna Peter Corrêa, Rafael Guerra Lund   +4 more
wiley   +1 more source

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

Protocol for quantifying miRNA trafficking across the endosomal membrane

FEBS Open Bio, EarlyView.
An in vitro protocol measures miRNA uptake into endosomes isolated from mammalian cell extracts, which are free of subcellular contaminants. Performed at 37 °C in the presence of ATP, it ensures the import of single‐stranded miRNA into the endosomal lumen.
Syamantak Ghosh, Kamalika Mukherjee, Suvendra N. Bhattacharyya   +2 more
wiley   +1 more source

Immunobiology of the Tomatine Adjuvant

, 2009
Soluble or sub-unit protein vaccines alone are incapable of generating antigen-specific cellular immune responses. This failure can be attributed to the manner in which the immune system processes antigen; endogenous antigens are cycled through the MHC ...
YANG, YA-WUN;NADEEM A. SHEIKH, 楊雅雯
core  

Transient Facial Nerve Paralysis (Bell's Palsy) following Intranasal Delivery of a Genetically Detoxified Mutant of Escherichia coli Heat Labile Toxin. [PDF]

, 2009
BACKGROUND: An association was previously established between facial nerve paralysis (Bell's palsy) and intranasal administration of an inactivated influenza virosome vaccine containing an enzymatically active Escherichia coli Heat Labile Toxin (LT ...
Kromann Ingrid, Woodrow, M, Novicki Deborah, Huo, Z, Del Giudice Giuseppe, Novicki, D, Rappuoli Rino, Thierry-Carstensen, B, Susan Barnett, Galiza, E, David J M Lewis, Rafaela Giemza, Andersen, P, Peter Andersen, Lewis David J. M., Barnett Susan, Maria Woodrow, Kromann, I, Giuseppe Del Giudice, Thierry-Carstensen Birgit, Giemza Rafaela, Ingrid Kromann, Andersen Peter, Lewis, DJ, Galiza Eva, Giemza, R, Huo Zhiming, Woodrow Maria, Deborah Novicki, Eva Galiza, Birgit Thierry-Carstensen, Rino Rappuoli, Del Giudice, G, Rappuoli, R, Barnett, S, Zhiming Huo   +35 more
core   +1 more source

A minimal cellulosome‐like system in Cellulosilyticum lentocellum

FEBS Open Bio, EarlyView.
Cellulose‐degrading bacteria typically use cellulosomes, large multi‐enzyme complexes on a scaffold protein. In Cellulosilyticum lentocellum, we characterise a far smaller arrangement, a single scaffold bound to one cellulase through a single cohesin‐dockerin interaction.
John Allan, Amias Alstrom‐Moore, Gary W Black   +2 more
wiley   +1 more source