Results 131 to 140 of about 791,952 (357)

Intelligent Thermo‐Self‐Limited Magnetothermia with Heat‐Triggered TERT Silencing for Precision Synergetic Cancer Therapy

Advanced Science, EarlyView.
Telomerase reverse transcriptase (TERT) mRNA induces DNA self‐assembly in cancer cells, boosting the nanoplatform's magnetothermal properties. This magnetothermia then activates the Hsp70 promoter, initiating siRNA synthesis to silence the TERT gene, enhancing cancer treatment.
Liang Zhang, Mingfu Gong, Tao Sun, Shilin Xiao, Yue Zhao, Xiaofeng Yang, Wansu Zhang, Chunyu Zhou, Xu Liu, Dong Zhang   +9 more
wiley   +1 more source

Trojan Horse Strategy: How Biomimetic Nanomedicine Remodels the Tumor Microenvironment

Advanced Science, EarlyView.
This review focuses on biomimetic nanomedicines for tumor microenvironment (TME) remodeling, covering their diverse biomimetic types, design principles, and mechanisms of immune cell reprogramming and reversal of immunosuppressive microenvironments, with particular emphasis on their application in synergistic immunotherapy.
Wanrong Wang, Siqi Mu, Juan Zhang, Guisong Shan, Xueqian Li, Ran Wang, Tao Guo, Xiaoyan He   +7 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Evaluation of the Effect of Radiotherapy Timing on Toxicity in HER2-Positive Breast Cancer Receiving Trastuzumab Emtansine During the Adjuvant Period

Acta Haematologica Oncologica Turcica
Aim: Breast cancer is the second leading cause of cancer-related deaths in women. Approximately 20-25% of breast cancers express HER2 and are associated with poor prognosis. With the use of HER2-targeted therapies, there has been an increase in treatment
İlknur Deliktaş Onur, Oğuzcan Kınıkoğlu, Gözde Kavgacı, Ömer Faruk Kuzu, Tuğba Başoğlu, Öztürk Ateş, Cengiz Karaçin   +6 more
doaj   +1 more source

Reliability of Reconstructed Breast Flap after Chemotherapy and Radiotherapy in Immediate Breast Reconstruction [PDF]

Archives of Plastic Surgery, 2012
BackgroundPostmastectomy adjuvant therapy is used to prevent locoregional recurrence and improve overall breast cancer specific survival rates. However, it can adversely affect the cosmetic results of reconstruction.
Keun-Cheol Lee, Tae-Heon Kim, Su-Seong Park, Min-Su Kim, Myung-Hoon Kim, Seok-Kwun Kim, Se-Heon Cho, Mi-Ri Lee, Jin-Hwa Lee, Hyung-Sik Lee, Dae-Cheol Kim   +10 more
doaj  

Radiotherapy with Concurrent and Adjuvant Pembrolizumab in Patients with P16-Positive Locoregionally Advanced Head and Neck Cancer: KEYCHAIN Trial Lead-In Results [PDF]

, 2019
Alessandra Sacco, Andrew B. Sharabi, Jing Zhao, Emily Pittman, Kathryn A. Gold, Whitney Sumner, Joseph A. Califano, Kevin T. Brumund, Ryan K. Orosco, Dominique Rash, C Coffey, E. Cohen, Loren K. Mell   +12 more
openalex   +1 more source

PATH-10. A CASE OF ADULT THALAMIC DIFFUSE MIDLINE GLIOMA, H3 K27-ALTERED WITH AN IMPRESSIVE RESPONSE TO RADIOTHERAPY AND CONCOMITANT PLUS ADJUVANT TEMOZOLOMIDE [PDF]

, 2022
Julien Rousseau, Moujahed Labidi, Jean-Paul Bahary, Karl Bélanger, France Berthelet, Sarah Lapointe   +5 more
openalex   +1 more source

Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma.

New England Journal of Medicine, 2005
R. Stupp, Warren P. Mason, M. J. van den Bent, M. Weller, B. Fisher, M. Taphoorn, K. Bélanger, A. Brandes, C. Marosi, U. Bogdahn, J. Curschmann, Robert C. Janzer, Samuel K. Ludwin, T. Gorlia, A. Allgeier, D. Lacombe, J. Cairncross, E. Eisenhauer, René O. Mirimanoff   +18 more
semanticscholar   +1 more source

Targeting WTAP/ROR1/WNT5A‐Mediated Crosstalk Between Glioma Stem Cells and Macrophages to Normalize Tumor Vasculature and Enhance Chemotherapy

Advanced Science, EarlyView.
In hypoxic microenvironment, WNT5A is predominantly secreted by tumor‐associated macrophages. Hypoxia‐induced WTAP mediates ROR1 stability by m6A modifications in a HuR‐dependent manner in Glioma stem cells (GSCs). WNT5A activates the WNT pathway via ROR1 binding on GSCs, driving glioma‐derived endothelial cells (GDECs) differentiation.
Xiaoyong Chen, Bo Pang, Yun Liu, Jiangwei Wang, Lanhui Zheng, Yuzhou Chang, Yingxuan Sun, Haoyuan Sun, Huiyuan Chen, Jiawei Cai, Zanyi Wu, Qing Chang, Yongzhi Wang, Dezhi Kang, Tao Jiang, Ruichao Chai   +15 more
wiley   +1 more source

Frequency of radiation-induced malignancies post-adjuvant radiotherapy for breast cancer in patients with Li-Fraumeni syndrome

Breast Cancer Research and Treatment, 2020
A. Le, J. Harton, H. Desai, J. Powers, Kristin Zelley, A. Bradbury, K. Nathanson, P. Shah, A. Doucette, G. Freedman, P. Gabriel, S. Domchek, Suzanne P. MacFarland, K. Maxwell   +13 more
semanticscholar   +1 more source